Virus entry: molecular mechanisms and biomedical applications
Membrane fusion — a basic cellular process that is essential for phagocytosis, pinocytosis and vesicular trafficking — is a basic mode of entry by enveloped viruses that use the endocytic or...
Mechanisms of SARS-CoV-2 entry into cells - Nature
2021年10月5日 · Receptor engagement by viral entry glycoproteins, typically with other triggers, induces dramatic conformational changes in both subunits that bring the viral and cellular …
Membrane Fusion and Viral Entry - Retroviruses - NCBI Bookshelf
There are two different pathways by which the interaction between virus and receptor leads to membrane fusion. Several enveloped viruses including influenza virus, VSV, and the …
Entry of Enveloped Viruses into Host Cells: Membrane Fusion
Enveloped viruses (i.e., viruses with a lipid envelope) use a two-step procedure to release their genetic material into the cell: (i) they first bind to specific surface receptors of the target cell …
Viral membrane fusion - Nature Structural & Molecular Biology
2008年7月3日 · Infection by viruses having lipid-bilayer envelopes proceeds through fusion of the viral membrane with a membrane of the target cell. Viral 'fusion proteins' facilitate this process.
Virus entry: molecular mechanisms and biomedical applications
Membrane fusion — a basic cellular process that is essential for phagocytosis, pinocytosis and vesicular trafficking — is a basic mode of entry by enveloped viruses that use the endocytic or …
Viral membrane fusion - ScienceDirect
2015年5月1日 · Enveloped viruses require membrane fusion to enter a cell. They expose on their surface many copies of a fusion protein, held in a “prefusion conformation” by constraints that …
SARS-CoV-2 entry and fusion are independent of ACE2 …
6 天之前 · Membrane fusion occurs at the early stages of SARS-CoV-2 replication, during entry of the virus, and later during the formation of multinucleated cells called syncytia. Fusion is …
Virus-Induced Cell Fusion and Syncytia Formation
2023年11月24日 · Most enveloped viruses encode viral fusion proteins to penetrate host cell by membrane fusion. Interestingly, many enveloped viruses can also use viral fusion proteins to …
Viral Membrane Fusion: A Dance Between Proteins and Lipids
Here we review current concepts about viral membrane fusion proteins focusing on how they are triggered, structural intermediates between pre- and postfusion forms, and their interplay with …