Type VII secretion systems: structure, functions and transport …
2021年5月26日 · Type VII secretion systems (T7SSs) have a key role in the secretion of effector proteins in non-pathogenic mycobacteria and pathogenic mycobacteria such as Mycobacterium tuberculosis, the...
Type VII secretion system - Wikipedia
Type VII secretion systems are bacterial secretion systems first observed in the phyla Actinomycetota and Bacillota. Bacteria use such systems to transport, or secrete, proteins into the environment. [1] . The bacterial genus Mycobacterium uses type VII secretion systems (T7SS) to secrete proteins across their cell envelope. [2] .
Type VII secretion systems: structure, functions and transport …
Type VII secretion systems (T7SSs) have a key role in the secretion of effector proteins in non-pathogenic mycobacteria and pathogenic mycobacteria such as Mycobacterium tuberculosis, the main causative agent of tuberculosis. Tuberculosis-causing mycobacteria, still accounting for 1.4 million deaths …
Type VII Secretion System - an overview | ScienceDirect Topics
To secrete a diverse range of effector proteins, mycobacteria have evolved to rely on the activities of a highly specialised secretion system - the type VII secretion system, also named the ESAT-6 secretion system (T7SS/ESX) (Bitter et al., 2009).
Evolving understanding of the type VII secretion system in Gram ...
2022年7月28日 · While most secretion systems are encoded by Gram-negative organisms, the type VII secretion system was discovered in Actinobacteria and then in Firmicutes (designated T7SSa and T7SSb, respectively) and has been implicated in development, interbacterial competition, nutrient acquisition, and virulence (Fig 1) .
Type VII secretion — mycobacteria show the way - Nature
Recent evidence shows that mycobacteria have developed novel and specialized secretion systems for the transport of extracellular proteins across their hydrophobic, and highly impermeable, cell...
Type VII secretion systems: structure, functions and
2021年5月26日 · Type VII secretion systems (T7SSs) have a key role in the secretion of effector proteins in non-pathogenic mycobacteria and pathogenic mycobacteria such as Mycobacterium tuberculosis, the...
Take five — Type VII secretion systems of Mycobacteria
2014年8月1日 · Mycobacteria use type VII secretion (T7S) systems to secrete proteins across their complex cell envelope. Pathogenic mycobacteria, such as the notorious pathogen Mycobacterium tuberculosis, have up to five of these secretion systems, named ESX-1 to ESX-5.
Structure and Function of the Mycobacterial Type VII Secretion …
In mycobacteria, type VII secretion systems (T7SSs) are dedicated protein transport machineries that fulfill diverse and crucial roles, ranging from metabolite uptake to immune evasion and subversion to conjugation.
Type VII Secretion: A Highly Versatile Secretion System
Type VII secretion (T7S) systems of mycobacteria secrete substrates over the unusual diderm cell envelope. Furthermore, T7S gene clusters are present throughout the phylum Actinobacteria, and functional T7S-like systems have been identified in Firmicutes.