Understanding the tumor immune microenvironment (TIME) for …
2018年4月23日 · It has been possible to identify different subclasses of immune environment that have an influence on tumor initiation and response and therapy; by parsing the unique classes and subclasses of...
The evolving tumor microenvironment: From cancer ... - Cell Press
2023年3月13日 · The evolving tumor microenvironment (TME) during all stages of cancer progression is depicted with key representative cell types shown. The TME includes diverse immune cells, cancer-associated fibroblasts (CAFs), endothelial cells, and the extracellular matrix (ECM), among others.
The tumor microenvironment: Current Biology - Cell Press
2020年8月17日 · To overcome a hypoxic and acidic microenvironment, the tumor microenvironment coordinates a program that promotes angiogenesis to restore oxygen and nutrient supply and remove metabolic waste. Tumors become infiltrated with diverse adaptive and innate immune cells that can perform both pro- and anti- tumorigenic functions (Figure 1).
The evolving tumor microenvironment: From cancer initiation to ...
2023年3月13日 · The tumor microenvironment (TME) includes diverse immune cell types, cancer-associated fibroblasts, endothelial cells, pericytes, and various additional tissue-resident cell types. These host cells were once considered bystanders of tumorigenesis but are now known to play critical roles in the pathogenesis of cancer.
Immune cells within the tumor microenvironment: Biological functions ...
2020年2月1日 · Recently, the development and application of new technologies such as single-cell RNA sequencing and mass cytometry in tumor immunology help to delineate the landscape of immune cells within TME at single-cell level, and make it easier to observe and identify new subsets of tumor-associated immune cells [[4], [5], [6], [7]]. In this review, we ...
Cancer organoids 2.0: modelling the complexity of the tumour immune …
2024年7月8日 · The intricate functional interactions between tumour cells and their immune microenvironment crucially regulate cancer progression and represent a substantial therapeutic opportunity.
Immune cells within the tumor microenvironment: Biological …
2020年2月1日 · The immune cells within the tumor microenvironment (TME) play important roles in tumorigenesis. It has been known that these tumor associated immune cells may possess tumor-antagonizing or tumor-promoting functions.
The updated landscape of tumor microenvironment and drug
2020年8月25日 · Accumulating evidence shows that cellular and acellular components in tumor microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and response to therapies....
Innate immune cells in the tumor microenvironment - Cell Press
2021年6月14日 · The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive and innate immune cells that have tumor-promoting and anti-tumor effects. There is still much to learn about the diversity, plasticity, and functions of innate immune cells in the TIME and their roles in determining the response to immunotherapies.
Tumor Microenvironment - PMC
Tumor cells stimulate significant molecular, cellular and physical changes within their host tissues. The emerging tumor microenvironment (TME) is a complex and continuously evolving entity. The composition of the TME varies between tumor types, but hallmark features include immune cells, stromal cells, blood vessels, and extracellular matrix ...
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