TAR DNA-binding protein 43 - Wikipedia
TDP-43 is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. In particular, TDP-43 is a splicing factor binding to the intron8/exon9 junction of the CFTR gene and to the intron2/exon3 region of the apoA-II gene.
TDP-43 proteinopathies: a new wave of neurodegenerative diseases
Putative mechanisms by which TAR DNA-binding protein 43 (TDP-43) exerts its pathogenic effects in TDP-43 proteinopathies. Multiple processes have been implicated in TDP-43 pathogenesis. Nuclear depletion of TDP-43 results in dysregulation of RNA metabolism resulting in reduced protein production.
The role of TDP-43 propagation in neurodegenerative diseases ...
2020年10月13日 · TAR DNA-binding protein 43 (TDP-43) is a highly conserved nuclear RNA/DNA-binding protein involved in the regulation of RNA processing.
The pathogenic mechanism of TAR DNA-binding protein 43 (TDP-43…
This review provides a preliminary overview of the potential effects of TAR DNA-binding protein 43 in the pathogenesis of amyotrophic lateral sclerosis, including the abnormalities in nucleoplasmic transport, RNA function, post-translational modification, liquid-liquid phase separation, stress granules, mitochondrial dysfunction, oxidative ...
TARDBP Gene - GeneCards | TADBP Protein | TADBP Antibody
2024年10月2日 · TARDBP (TAR DNA Binding Protein) is a Protein Coding gene. Diseases associated with TARDBP include Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia and Motor Neuron Disease .
Regulation of TAR DNA binding protein 43 (TDP-43) …
2024年11月15日 · TAR DNA-binding protein 43 (TDP-43), encoded by the Tardbp gene, is mostly found in the nucleus but shuttles between the nucleus and cytoplasm to regulate RNA metabolism, such as transcription, translation, pre-mRNA splicing, and mRNA stability 1, 2, 3, 4.
TDP-43 proteinopathy in ALS is triggered by loss of ASRGL1 and
2024年5月16日 · TAR DNA-binding protein 43 (TDP-43) proteinopathy in brain cells is the hallmark of amyotrophic lateral sclerosis (ALS) but its cause remains elusive.
Seeding-competent TDP-43 persists in human patient and mouse …
5 天之前 · TAR DNA binding protein 43 (TDP-43) is a ubiquitously expressed RNA binding protein that is primarily localized to cell nuclei ().However, certain disease conditions cause TDP-43 to form cytoplasmic aggregates, resulting in interruption of RNA processing and disruption of protein homeostasis ().TDP-43 aggregation has been most frequently studied in the context of …
TAR DNA-binding protein 43 in neurodegenerative disease
2010年3月16日 · TAR DNA-binding protein 43 (TDP-43) inclusions are the main histopathological feature of amyotrophic lateral sclerosis (ALS) and many cases of frontotemporal lobar degeneration (FTLD).
TAR DNA-binding protein 43 oligomers in physiology and …
In this review, we emphasize the role of oligomeric TDP-43 in both physiological and pathological conditions and discuss the potential mechanisms of oligomer formation. Finally, we suggest therapeutic strategies against the TDP-43 oligomers in neurodegenerative diseases.