TGF beta 1 - Wikipedia
Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth , cell proliferation , cell differentiation , and apoptosis .
Transforming growth factor beta - Wikipedia
Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three [1] different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins.
TGF-β signaling in health, disease and therapeutics
2024年3月22日 · The signal transduction of TGF-β can stimulate diverse cellular responses and is particularly critical to embryonic development, wound healing, tissue homeostasis, and immune homeostasis in...
TGFB1 gene - MedlinePlus
The TGFB1 gene provides instructions for producing a protein called transforming growth factor beta-1 (TGFβ-1). Learn about this gene and related health conditions.
Transforming Growth Factor Beta 1 - ScienceDirect
Transforming growth factor β1 (TGF-β1) is a multifunctional cytokine that plays important roles in cervical neoplasia formation, invasion, progression, and metastasis. TGF-β1 functions as a tumor inhibitor in precancerous lesions and early-stage cancers of cervix whereas as a …
Transforming growth factor-β receptors: versatile mechanisms ...
2024年2月13日 · Transforming growth factor-β (TGF-β) signaling is initiated by activation of transmembrane TGF-β receptors (TGFBR), which deploys Smad2/3 transcription factors to control cellular...
TGF-β signaling in health and disease - Cell Press
2023年9月14日 · TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury repair through coordinated effects on cell proliferation, phenotypic plasticity, migration, metabolic adaptation, and immune surveillance of multiple cell types in shared ecosystems.
Transforming Growth Factor Beta Family: Insight into the Role ...
The transforming growth factor beta (TGF-β) family forms a group of three isoforms, TGF-β1, TGF-β2, and TGF-β3, with their structure formed by interrelated dimeric polypeptide chains. Pleiotropic and redundant functions of the TGF- β family concern control of numerous aspects and effects of cell functions, including proliferation ...
TGF-beta signal transduction: biology, function and therapy ...
2022年12月19日 · The transforming growth factor beta (TGF-β) is a crucial cytokine that get increasing concern in recent years to treat human diseases. This signal controls multiple cellular responses during embryonic development and tissue homeostasis through canonical and/or noncanonical signaling pathways.
Latent TGF-β structure and activation - Nature
2011年6月15日 · Crystals of dimeric porcine proTGF-β1 reveal a ring-shaped complex, a novel fold for the prodomain, and show how the prodomain shields the growth factor from recognition by receptors and alters its...