Lithiation–borylation methodology in the total synthesis of natural ...
2022年2月7日 · In this Review, we highlight the fundamentals of the methodology and the key features that lead to high levels of control together with its applications in synthesis. Fundamental work on the...
Synthesis of Pyridine−Borane Complexes via Electrophilic …
2010年11月23日 · Pyridine−borane complexes were synthesized from 2-arylpyridines through an electrophilic aromatic borylation reaction with BBr 3. The intermediate 2- (2-dibromoborylaryl)pyridines were stable enough to be handled in air and served as the synthetic platform for variously substituted pyridine−borane complexes.
One-pot synthesis of four-coordinate boron (III) complexes by the ...
2017年3月21日 · Here, we report a metal-free one-pot synthesis of four-coordinate organoborons using boronic acids, which represents the first instance of ligand assisted organic group migration between...
Recent synthetic methodologies for pyrimidine and its …
2018年12月6日 · synthesize the pyrimidine ring and its deriv atives, which include multicomponent synthesis, condensation of chalcones with urea/thiourea, coupling of imidamide/guanidine with various reagents...
Synthetic Approaches for Pharmacologically Active Decorated Six ...
2022年12月21日 · Special attention will be given to novel synthetic methodologies that served molecules with improved druglikeness and ADME-Tox properties. 1. Introduction. Pyrimidine derivatives, broadly applied in therapeutic disciplines, owing to …
Synthesis and spectroscopic properties of 4,4′-bipyridine linker ...
2021年6月7日 · Besides, boron is involved in the nucleic acid synthesis and possibly linked to adequate provision of the pyrimidine nucleotides. Boron also plays a part in carbohydrate metabolism, hormone action, and membrane formation [14].
Proficient synthesis of bioactive annulated pyrimidine derivatives…
2017年11月1日 · The one-pot syntheses of targeted annulated pyrimidine utilize multicomponent solutions of active methylene compounds and aromatic aldehydes with or without catalyst and solvents under various conditions. The reports in the literature also showed the synthesis of targeted annulated pyrimidines using both conventional and non-conventional ...
Metal-Free Synthesis of C-4 Substituted Pyridine Derivatives …
2017年2月17日 · With the unique reactivity of such radicals, 4-substituted pyridine derivatives could be synthesized using α,β-unsaturated ketones and 4-cyanopyridine via a novel radical addition/C—C coupling mechanism. Several controlled experiments were conducted to provide supportive evidence for the proposed mechanism.
Synthesis and photophysical investigations of pyridine ... - Nature
2022年10月1日 · Bearing in mind the importance of fluorescent dyes, herein we have designed and synthesised a new family of boron complexes based on pyridine-pyrazolate ligands with improved features including...
Pd(II)-Catalyzed Three-Component Synthesis of Furo[2,3-d]pyrimidines …
A Pd (II)-catalyzed three-component synthesis of 2,4,6-triarylfuro [2,3- d]pyrimidines from β-ketodinitriles, boronic acids, and aldehydes has been developed. The participation of both nitrile (−CN) groups led to the concurrent construction of furo-pyrimidine via the formation of C–C, C═C, C–O, C–N, and C═N bonds.