Synthesis and Characterization of Novel Succinyl Chitosan-Dexamethasone …
2021年10月11日 · Under the conditions studied, the hydrolysis rate of the succinyl linker at the amide bond was higher than at the ester bond, which resulted in the favorable formation of …
Synthesis and Characterization of Novel Succinyl Chitosan-Dexamethasone …
2021年10月11日 · The size of the obtained particles was 400–1100 nm, and the ζ-potential was −30 to −33 mV. In vitro release studies at pH 7.4 showed slow hydrolysis of the amide and …
Synthesis and Pharmacology of Anti-inflammatory Steroidal Antedrugs
Among them the (20S)-succinyl dexamethasone derivatives (92) displayed more or less potent anti-inflammatory activity than the parent dexamethasone and did not show corticosteroidal …
Dexamethasone Conjugates: Synthetic Approaches and Medical …
Dexamethasone (DEX) is the most commonly prescribed glucocorticoid (GC) and has a wide spectrum of pharmacological activity. However, steroid drugs like DEX can have severe side …
用于潜在玻璃体内地塞米松递送的新型琥珀酰壳聚糖-地塞米松偶联 …
玻璃体内糖皮质激素递送系统的开发是当前治疗眼后段炎性疾病的全球性挑战。这些系统的主要优点是它们可以克服眼科的解剖和生理障碍，提高局部生物利用度，同时延长和控制药物释放数 …
Covalently crosslinked hyaluronic acid‐chitosan hydrogel …
2012年11月22日 · The gelation is attributed to the Schiff-base reaction between amino and aldehyde groups of hydrogel precursors. In this article, the water soluble chitosan, N-succinyl …
Synthesis and Characterization of Novel Succinyl Chitosan-Dexamethasone …
2021年10月11日 · This study focuses on the development of a procedure for a two-step synthesis of dexamethasone (DEX) conjugates based on the natural polysaccharide chitosan (CS).
Dexamethasone Conjugates: Synthetic Approaches and Medical …
2021年3月27日 · Dexamethasone (DEX) is the most commonly prescribed glucocorticoid (GC) and has a wide spectrum of pharmacological activity. However, steroid drugs like DEX can …
Mucoadhesive cholesterol-chitosan self-assembled particles for …
The aim of this study was to obtain dexamethasone-loaded mucoadhesive self-assembled particles based on a conjugate of succinyl cholesterol with chitosan (SC-CS) for potential use …
synthesis of dexamethasone (DEX) conjugates based on the natural polysaccharide chitosan (CS). We first used carbodiimide chemistry to conjugate DEX to CS via a succinyl linker, and …