Pharmaceutical amorphous solid dispersion: A review of …
2021年8月1日 · Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and bioavailability of poorly water-soluble drugs. Various approaches have been employed to produce ASDs and novel techniques are emerging. This review provides an updated overview of manufacturing techniques for preparing ASDs.
Fundamental aspects of solid dispersion technology for poorly soluble ...
2014年2月1日 · In this review, we summarize our current understanding of solid dispersions both in the solid state and in dissolution, emphasizing the fundamental aspects of this important technology. A solid dispersion is basically a drug–polymer two-component system in which the mechanism of drug dispersion is the key to understanding its behavior.
(PDF) Review Article SOLID DISPERSION: ITS TYPES AND …
2019年1月1日 · Solid dispersion, defined as the dispersion of one or more active ingredient in a carrier or matrix at solid state, is an efficient strategy for improving dissolution of poorly water-soluble...
Solid dispersions: A technology for improving bioavailability
2019年1月30日 · Solid dispersion is a solubilization technology emphasizing basically on drug-polymer two component systems in which drug dispersion and its stabilization is the key for formulation development.
Amorphous solid dispersions: Stability mechanism, design …
2023年11月5日 · Solid dispersion (SD) system has been used as an effective formulation strategy to increase in vitro and in vivo performances of poorly water-soluble drugs, such as solubility/dissolution, stability and bioavailability. This review provides a comprehensive SD classification and identifies the most popular amorphous solid dispersions (ASDs).
A collection of solid products with at least two distinct components—typically a hydrophilic inert carrier or matrix and a hydrophobic drug—are referred to as solid dispersions. This article consists of the origins, categorization, procedures and advantages and drawbacks of several preparation methods for solid dispersion technology.
Solid dispersion technology as a formulation strategy for the ...
2022年4月18日 · Solid dispersions are widely used in different solid dosage forms like powders, granules, capsules, tablets, pellets or films with the purpose of improving solubility and the dissolution rate [49,50,51].
Amorphous solid dispersions of enzalutamide and novel ... - Nature
2020年10月28日 · Amorphous solid dispersion (ASD) is a widely employed formulation technique for drugs with poor aqueous solubility. Polymers are integral components of ASDs, but mechanisms by which polymers lead...
Solid dispersions: a review - PubMed
Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. This article reviews the various preparation techniques for solid dispersion and compiles some of the recent technology transf …
Solid dispersions as strategy to improve oral bioavailability of …
Solid dispersions are one of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. By reducing drug particle size to the absolute minimum, and hence improving drug wettability, bioavailability may be significantly improved.
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