Biological membranes are bilayers formed by membrane lipids, with a hydrophobic core and hydrophilic surfaces. Membranes are generally stable in an aqueous environment an… 展开

Protein-free lipid membranes do not fuse spontaneously in aqueous media under p… 展开

SNAREs represent a unique class of fusion proteins. Single SNARE molecules are not active and cannot fuse membranes even if present at high concentrations. For fusion, SNARE proteins … 展开

As detailed above (Fig. 1), the pathway of membrane fusion involves sequential steps separated by energy barriers. Fusion proteins such as SNAREs transfer conformational e… 展开

Since the discovery of the SNARE fusion machinery about 30 years ago, major progress was made not only in the detailed understanding of the SNARE machinery with its complex … 展开