Cholinergic crisis - Wikipedia
A cholinergic crisis is an over-stimulation at a neuromuscular junction due to an excess of acetylcholine (ACh), [1] as a result of the inactivity of the AChE enzyme, which normally breaks down acetylcholine.
SLUDGE: Cholinergic Crisis Signs and Symptoms Acronym
2024年8月23日 · SLUDGE is an acronym used to remember the symptoms of a cholinergic crisis. These include increased salivation and sweating, lacrimation, urinary frequency, diarrhea, gastrointestinal cramping, and emesis or vomiting.
Cholinergic crisis - WikEM
If any fasciculations, respiratory depression, or cholinergic symptoms within a few minutes, problem is likely cholinergic crisis (no more edrophonium). If no evidence of cholinergic excess, give total of 10mg and observe improvement in case of myasthenic crisis.
Cholinergic Crisis - StatPearls - NCBI Bookshelf
2020年9月4日 · Cholinergic crisis is a clinical condition that develops as a result of overstimulation of nicotinic and muscarinic receptors at the neuromuscular junctions and synapses. This is usually secondary to the inactivation or inhibition of acetylcholinesterase (AChE), the enzyme responsible for the degradation of acetylcholine (ACh).
Cholinergic Toxicity - StatPearls - NCBI Bookshelf
2022年12月5日 · Cholinergic toxicity occurs when too much acetylcholine is present in the receptor synapse leading to excessive parasympathetic effects. This activity reviews the presentation, evaluation, and management of cholinergic toxicity and stresses the role of an interprofessional team approach to the care of affected patients. Objectives:
Toxidromes: Common Poisoning Syndromes to Know - JEMS
2021年2月18日 · Exposure to cholinergic agents or an overdose of a cholinergic medication will often have a classic set of signs and symptoms. 9 A popular mnemonic known as “SLUDGE” 10 (or sometimes referred...
Anticholinergic toxicity - WikEM
Side effects: bradycardia, dysrhythmias, cholinergic excess; Always have atropine at the bedside for bradycardia or cholinergic excess</ref> Contraindicated in TCA toxicity (associated with cardiac arrest) and in the presence of bradycardia or AV block; Other therapies. Sodium bicarbonate for conduction abnormalities (QRS prolongation)
SLUDGE: Cholinergic Crisis Signs and Symptoms Acronym
With high-power magnification and electron microscopy, we can identify some of the different parts of the sarcomere that form the striations, such as the A band, I band, and the Z discs that run down the middle of the I bands.
Cholinergic Syndrome (Cholinergic Toxicity) - Toxicology and …
2019年7月6日 · Acute cholinergic syndrome includes signs and symptoms caused by the stimulation of muscarinic and nicotinic receptors. This may be due to excess acetylcholine caused by the inhibition of enzymes like acetylcholinesterase (AChE), which degrades acetylcholine, or due to exogenous parasympathetic stimulants. Causes:
Cholinergic Crisis - an overview | ScienceDirect Topics
Cholinergic crisis may develop from overdoses of acetylcholinesterase inhibitors or exposure to nerve gases such as Sarin or organophosphate insecticides such as malathion. The crisis is signified by signs of muscle paralysis, respiratory failure, increased respiratory secretions, seizures, coma, and death.