Genotype relative risks: methods for design and analysis of
We present analysis methods which are based on two genetic relative risks: (1) the relative risk of disease for homozygotes with two copies of the candidate gene versus homozygotes without the candidate gene and (2) the relative risk for heterozygotes with one copy of the candidate gene versus homozygotes without the candidate gene.
RR值、OR值、HR值：临床研究中的3个“R”你都分清了吗? - 知乎
相对危险度RR（relative risk）、风险比HR（hazard ratio）、比值比OR（odds ratio），以上三个“R”值在临床研究领域有着广泛的应用，但对于不少临床新手来说，一看见这三个概念就容易搞混，更别提真正理解它们背…
Basic statistical analysis in genetic case-control studies
A commonly used and intuitive measure of the strength of an association is the relative risk (RR), which compares the disease penetrances between individuals exposed to different genotypes. Special relationships exist between the RRs for these common models 9 (see Table 1). TABLE 1.
Genotype relative risks: methods for design and analysis of …
We present analysis methods which are based on two genetic relative risks: (1) the relative risk of disease for homozygotes with two copies of the candidate gene versus homozygotes without the candidate gene and (2) the relative risk for heterozygotes with one copy of the candidate gene versus homozygotes without the candidate gene.
Calculating RISK for complex traits • Start with your population prior for T2D: for CEU men, we use 0.237 (corresponding to LR of 0.237 / (1 – 0.237) = 0.311).
Genetic risks and genetic model specification - ScienceDirect
2016年8月21日 · A genetic model is defined in terms of two genetic risk measures: genotype relative risk and odds ratio. The impacts of choosing a risk measure on the resulting genetic models are studied in the power to detect association and deviation from Hardy–Weinberg equilibrium in cases using genetic relative risk.
Estimating genotype relative risks - PubMed
When a disease is rare in the general population, genotype relative risks can be estimated from case-control data by adjusting the genotype frequencies in controls to the expected Hardy-Weinberg proportions. The resulting risk estimates are shown to have a smaller variance than those obtained from t …
[PDF] Genotype relative risks: methods for design and analysis of ...
We present analysis methods which are based on two genetic relative risks: (1) the relative risk of disease for homozygotes with two copies of the candidate gene versus homozygotes without the candidate gene and (2) the relative risk for heterozygotes with one copy of the candidate gene versus homozygotes without the candidate gene.
The Relationship between the Sibling Recurrence-Risk Ratio and Genotype …
The former is generally quantified as a genotype relative risk, γ, and measures the ratio of disease risks between those with and those without the susceptibility genotype(s). We demonstrate that λ S varies significantly more with respect to γ and the disease-allele frequency for two-locus multiplicative models than for other two-locus and ...
Estimating genotype relative risks in case-parental control
2000年9月1日 · It can quantify the relations between candidate genes and disease risk. Previous authors have proposed noniterative methods for estimating "genotype relative risks" (GRRs) in case-parental control studies.