An overview of mechanisms of redox signaling - PMC - PubMed …
Redox signaling requires an electrophile (a molecule that attracts electrons) reacting with a nucleophile (a molecule that will give up electrons). There are thus two major types of reactions in redox signaling. One involves reactions in which the electrophile takes electrons away leaving the nucleophile in a more oxidized state.
Redox metabolism: ROS as specific molecular regulators of cell ...
2021年9月16日 · In this review, we focus specifically on intracellular redox signaling processes, highlighting the wide-ranging effect of redox regulation on cell function, as well as implications of redox imbalance in pathophysiology.
Using redox-sensitive fluorescent probes to record real-time …
Here, we present a protocol to record acute changes in ROS production in sensory cells from mouse carotid body (CB) slices using redox-sensitive green fluorescent protein probes and microfluorimetry. This protocol provides sensitive and reproducible quantification of ROS during acute hypoxia in different subcellular compartments of CB glomus cells.
ROS Function in Redox Signaling and Oxidative Stress
2014年5月19日 · Redox signaling is required for numerous cellular processes, as indicated by the role of ROS in proper cellular differentiation, tissue regeneration, and prevention of aging. However, we propose that redox signaling, and not oxidative stress, is also crucial in regulating signaling pathways that control various disease states, including ...
Redox signaling-driven modulation of microbial biosynthesis and ...
2023年10月26日 · In the redox communication network, the Fe 3+ /Fe 2+ redox signal can be dynamically and reversibly transduced, channeling electrons directly and specifically into bio-actuator cells through...
Redox metabolism: ROS as specific molecular regulators of cell ...
Redox signaling is a key regulator of cell metabolism and physiology. In this review, Lennicke and Cochemé highlight the impressive diversity of intracellular processes under redox control and provide insight into the pathophysiological role of redox imbalance in …
Cellular mechanisms and physiological consequences of redox …
2014年5月23日 · Members of the NADPH oxidase (NOX) family are important generators of intracellular ROS and have an important role in reduction–oxidation (redox) signalling. Most redox signalling occurs by the...
Redox Signaling from Mitochondria: Signal Propagation and Its …
2020年1月6日 · Examples of mitochondrial redox signaling are discussed: initiation of hypoxia-inducible factor (HIF) responses; retrograde redox signaling to PGC1α during exercise in skeletal muscle; redox signaling in innate immune cells; redox stimulation of insulin secretion, and other physiological situations.
Redox in Molecular Signaling
Researchers in this group focus on mechanically-induced molecular responses by anti-clotting drugs (integrin signaling), mechanical properties of nanofibers involved in signaling, characterization of of transport within cells, alteration of DNA structure by chemotherapeutics and DNA-protein assemblies, signaling resulting from mechanoperception ...
Reactive oxygen species and cell signaling. Review☆
2024年2月1日 · Superoxide signaling is thought to affect the redox state of transition metal ion complexes in proteins and can be regulated by SODs. Examples include superoxide-dependent disruption of the iron‑sulfur (Fe S) cluster in aconitase, and inactivation of the Fe S form of mitochondrial glutaredoxin 2.