HER3：HER家族的怪胎，能否成药？ - 知乎专栏
2021年11月14日 · her蛋白是一个受体酪氨酸激酶家族，在正常和肿瘤细胞生物学中都发挥着作用。该家族包括四个高度同源的成员：egfr（erbb1/her1）、her2(erbb2)、her3(erbb3)和her4(erbb4)，它们都由四部分组成：配体结合的细胞外结…
谢晖教授：旧靶新药，HER3-ADC将书写新的乳腺癌治疗篇章 …
2023年6月15日 · 编者按：人表皮生长因子受体3（HER3）是HER家族成员，虽然激酶活性较弱，但在肿瘤进展和耐药性发展中扮演重要角色。 HER3发现迄今已有三十多年，但针对该靶点的药物研究仍“颗粒无收”，尚无一款靶向HER3的药物获批临床。 近年来，双特异抗体及抗体偶联药物（ADC）在靶向HER3治疗中带来曙光，尤其是HER3-DXd已在乳腺癌领域，有多项临床研究展现了积极的治疗效果和安全性。 在全球瞩目的2023年ASCO盛会上，一项HER3-DXd治疗晚期 …
HER3: Unmasking a twist in the tale of a previously unsuccessful ...
2024年6月17日 · HER3 plays a significant pro-cancer role in various types of cancer due to its overexpression and abnormal activation, which initiates downstream signaling pathways crucial in cancer cell survival and progression. As a result, numerous monoclonal antibodies have been developed to block HER3 activation and subsequent signaling pathways.
异源二聚体中，NRG1/HER3/HER2复合物的活性最 强，可以强烈地激活PI3K/AKT信号级联以及RAS/ 分裂素原活化蛋白激酶（ mitogen-activated protein kinases，MAPK）通路，增强细胞的存活和增殖[19]。 3 HER3介导的NSCLC的进展 HER3 在各种癌症中普遍表达，包括乳腺癌、 。 。 。
HER3: Updates and current biology function, targeted therapy and ...
2024年11月15日 · Increasing evidence has shown that high expression of HER3 is also associated with disease progression, metastatic events and poor prognosis of several cancers, and that HER3 is a driver of drug resistance and a mediator of drug resistance in targeted therapies, making HER3 an important and valuable prognostic biomarker.
Targeting HER3 for cancer treatment: a new horizon for an old …
2023年2月8日 · HER3 is a tyrosine kinase receptor belonging to the HER family, ubiquitously expressed across different solid tumors. HER3 has a role in tumorigenesis, disease progression, metastatic dissemination and anticancer drugs’ resistance. Monoclonal antibodies and bispecific antibodies targeting HER3 have led to unsatisfactory results.
HER3: Toward the Prognostic Significance, Therapeutic Potential ...
HER3 has been found to promote tumorigenesis, tumor growth, and drug resistance in different cancer types, especially breast and non-small cell lung cancer. Given its ubiquitous expression across different solid tumors and role in oncogenesis and drug resistance, there has been a long effort to target HER3.
30 years of HER3: From basic biology to therapeutic interventions
HER3 is an exceptional EGFR family member that is not oncogenic alone, but can cooperate with other receptors to induce tumorigenesis, metastatic events, and drug resistance. HER3 is a compelling cancer therapeutic target, but so far, no HER3 …
Thirty Years of HER3: From Basic Biology to Therapeutic …
2021年7月1日 · In this review article, we discuss the most recent HER3 biology in tumorigenic events and drug resistance and provide an overview of the current and emerging strategies to target HER3. The HER proteins are a family of receptor tyrosine kinases that play a role in both normal and tumor cell biology.
A critical role for HER3 in HER2-amplified and non-amplified …
2015年4月15日 · A unique feature of GE-huMab-HER3 that differentiates it from other anti-HER3 antibodies is its ability to bind to human FcγRIIIa on immune effector cells with a 50-fold higher affinity than standard IgG1 antibodies.