Pyrimidine dimer - Wikipedia
Pyrimidine dimers encompass several types, each with distinct structures and implications for DNA integrity. Cyclobutane pyrimidine dimer (CPD) is a dimer which features a four-membered ring formed by the fusion of two double-bonded carbons from adjacent pyrimidines.
DNA Repair - The Cell - NCBI Bookshelf
The major type of damage induced by UV light is the formation of pyrimidine dimers, in which adjacent pyrimidines on the same strand of DNA are joined by the formation of a cyclobutane ring resulting from saturation of the double bonds between carbons 5 and 6 (see Figure 5.20A).
9.3: DNA Repair - Biology LibreTexts
Pyrimidine Dimerization UV light exposure of DNA can cause adjacent pyrimidines (commonly thymines; less often, cytosines) on a DNA strand to dimerize. Pyrimidine dimers form at a rate of a bit less than 100 per cell per day!
Pyrimidine Dimer - an overview | ScienceDirect Topics
A pyrimidine dimer is an intrastrand DNA cross-link caused by exposure to ultraviolet light, which can block DNA replication and transcription. Various DNA repair mechanisms exist to remove pyrimidine dimers, as defects in their removal can lead to diseases and cancer in humans.
Pyrimidine Dimer - an overview | ScienceDirect Topics
Thymine dimers occur when DNA is exposed to UV radiation. The most common form, cis-syn cyclobutane pyrimidine dimer (CPD), is a strong block to replicative DNA polymerases.
Pyrimidine Dimer - an overview | ScienceDirect Topics
Pyrimidine dimers are structures that form between two of four nucleotide bases that make up DNA: the nucleotides cytosine and thymine, which are members of the chemical family called pyrimidines. From: Animal Biotechnology, 2014
DNA excision repair - PMC - National Center for Biotechnology …
2012年8月8日 · Exposure of cells to UV light from the sun causes the formation of pyrimidine dimers in DNA that have the potential to lead to mutation and cancer. In humans, pyrimidine dimers are removed from the genome in the form of ~30 nt …
The Molecular Perspective: Ultraviolet Light and Pyrimidine Dimers ...
2009年1月1日 · Pyrimidine dimer in DNA. A TT dimer (in violet) is shown within a DNA double helix. Notice the four-membered cyclobutane ring formed between the two thymine bases. The dimer causes local distortions in the helix, weakening the interaction with the paired adenine bases and kinking the backbone slightly.
Pyrimidine dimer | C8H8N4 | CID 22057568 - PubChem
2021年10月14日 · Pyrimidine Dimer is a pair of pyrimidine bases (thymine or cytosine in DNA or uracil in double-stranded RNA) within a nucleic acid covalently linked by a cyclobutane ring, the formation of which was induced by exposure to ultraviolet radiation.
7.3: Ionizing Radiation - Biology LibreTexts
2023年6月20日 · Ultraviolet radiation with a wavelength of 260 nm will form pyrimidine dimers between adjacent pyrimidines in the DNA. The dimers can be one of two types (Figure 7.11). The major product is a cytobutane-containing thymine dimer (between C5 and C6 of adjacent T's).