Altered propionate metabolism contributes to tumour ... - Nature
2022年3月31日 · To characterize the relevant metabolic changes that promote cancer progression, we identified significantly altered metabolites in pulmonary metastases compared to corresponding primary tumours in...
Propanoate Metabolism | Pathway - PubChem
2020年4月3日 · In a rare genetic metabolic disorder called propionic acidemia, propionate acts as a metabolic toxin in liver cells by accumulating in the liver mitochondria as propionyl-CoA and its derivative methylcitrate.
Propionate as a health-promoting microbial metabolite in the …
2011年5月1日 · Propionate is a major microbial fermentation metabolite in the human gut with putative health effects that extend beyond the gut epithelium. Propionate is thought to lower lipogenesis, serum cholesterol levels, and carcinogenesis in other tissues.
Disrupted propionate metabolism evokes transcriptional …
2023年11月23日 · We found that a global genetic disruption to propionate metabolism raises cardiac propionate and propionyl-CoA to levels that cause histone propionylation and a net increase in acetylation in...
Comparative aspects of propionate metabolism - PubMed
The catabolism of propionate has been studied extensively in vertebrates and the major pathway has been shown to be its derivatization to propionyl-CoA, carboxylation to D-methylmalonyl-CoA, isomerization to L-methylmalonyl-CoA and then conversion to succinyl-CoA via a vitamin B12 dependent methy …
Altered propionate metabolism contributes to tumour ... - PubMed
2022年4月2日 · The alteration of metabolic pathways is a critical strategy for cancer cells to attain the traits necessary for metastasis in disease progression. Here, we find that dysregulation of propionate metabolism produces a pro-aggressive signature in breast and lung cancer cells, increasing their metastati …
Propionic acid - Wikipedia
Propionic acid (/ p r oʊ p i ˈ ɒ n ɪ k /, from the Greek words πρῶτος : prōtos, meaning "first", and πίων : píōn, meaning "fat"; also known as propanoic acid) is a naturally occurring carboxylic acid with chemical formula CH 3 CH 2 CO 2 H.It is a liquid with a pungent and unpleasant smell somewhat resembling body odor.The anion CH 3 CH 2 CO − 2 as well as the salts and ...
Propionate metabolism and diversity of relevant functional …
2017年9月23日 · Propionate is a common metabolic intermediate occurring in environmental samples including petroleum reservoirs. Available microbial genomes were obtained from the NCBI database and analyzed in silico by hmmscan to check three metabolic pathways of propionate production in petroleum reservoir system …
Development of a propionate metabolism-related gene-based …
Dysregulated propionate metabolism, a key cancer factor, suggests a potential target for treating metastatic cancer. However, a complete understanding of the link between propionate metabolism-related genes (PMRGs) and bladder cancer is lacking.
Development and Validation of a Propionate Metabolism …
Studies have demonstrated that propionate metabolism-related genes (PMRGs) are associated with cancer progression. PMRGs are not known to be involved in Hepatocellular carcinoma (HCC). In this study, The Cancer Genome Atlas (TCGA) and Gene ...