Micellar Morphology of Polysorbate 20 and 80 and Their Ester …
2020年4月1日 · The microstructure of micelles in aqueous solution of all-laurate PS20 and all-oleate PS80, as well as the monoester and diester fractions and their mixtures, are measured and reported at temperatures pertinent to biopharmaceutical formulation stability studies. The micelle size and aggregation number increase with increasing temperature.
Molecular dynamics simulation of a polysorbate 80 micelle in water
The structure and dynamics of a single molecule of the nonionic surfactant polysorbate 80 (POE (20) sorbitan monooleate; Tween 80®) as well as a micelle comprising sixty molecules of polysorbate 80 in water have been investigated by molecular dynamics simulation.
Preservative Induced Polysorbate 80 Micelle Aggregation
2021年6月1日 · Solutions of two common protein formulation excipients, polysorbate 80 (PS80), a nonionic surfactant that prevents aggregation, and m-cresol, an antimicrobial agent for multi-dose injectable formulations, are investigated. The addition of m-cresol to PS80 solutions leads to solution turbidity and irreversibly alters PS80 micelle morphology.
Predicting critical micelle concentration and micelle molecular …
2015年8月1日 · Detailed analysis of polysorbate 80 and correlation with physical methods. Predictive model for critical micelle concentration using compendial methods. Description of impact of several analytical outcomes on functionality related characteristics.
Surface Tension and Self-association Properties of Aqueous
2020年8月28日 · This study focusses on the determination of the self-association properties of compendial grade polysorbate 20 HP (PS 20 HP) and polysorbate 80 HP (PS 80 HP) with regard to the formed micelle size (by dynamic light scattering, DLS), the concentration upon which the surfactant molecules self-associate (cmr, critical micelle concentration range ...
Morphology of polysorbate 80 (Tween 80) micelles in aqueous …
The structures of micelles of the surfactant polysorbate 80 (Tween 80) in 0–50% aqueous dimethyl sulfoxide (DMSO) solutions (pH 7.2, ionic strength 2.44 mM) were investigated by means of small-angle X-ray scattering. At DMSO concentrations of 0–20%, core–shell cylinder micelles formed, and at 30–50% DMSO, core–shell discus micelles ...
Predicting critical micelle concentration and micelle molecular weight ...
This manuscript addresses the capability of compendial methods in controlling polysorbate 80 (PS80) functionality. Based on the analysis of sixteen batches, functionality related characteristics (FRC) including critical micelle concentration (CMC), cloud …
Micellar Morphology of Polysorbate 20 and 80 and Their Ester …
2019年12月1日 · Here, we present a novel solution for PS-80 characterization using ultra high-performance liquid chromatography coupled with charge-reduction high resolution mass spectrometry.
Predicting critical micelle concentration and micelle molecular …
2014年12月13日 · Similarly, a four parameter model based on chemical analyses alone was instrumental in predicting the molecular weight of PS80 micelles. Improved models based on analytical outcome from...
Biocompatible polymeric micelles with polysorbate 80 for use
2008年12月3日 · Polymeric micelles from PHEA-EDA-PLA and PHEA-EDA-PS (80)-PLA copolymers were obtained by using the dialysis method and were characterized in terms of mean size, zeta potential, critical aggregation concentration (CAC), and surface composition by x-ray photoelectron spectroscopy (XPS) analysis, which demonstrated the presence of …