Investigating PLGA microparticle swelling behavior reveals an …
2021年7月15日 · This study analyzes the swelling behavior of native, unmodified, spherically uniform, monodisperse poly(lactic-co-glycolic acid) (PLGA) microparticles in a robust high-throughput manner.
Effect of acidic pH on PLGA microsphere degradation and release
2007年10月8日 · Polymer degradation and drug release kinetics from PLGA microspheres were investigated under neutral and acidic pH conditions. Two different Mw formulations (Mw: 25,000 and 70,000) were investigated and both exhibited a …
Acidic Microclimate pH Distribution in PLGA Microspheres …
The microclimate pH (μpH) distribution inside poly(lactic-co-glycolic acid) (PLGA) microspheres was monitored quantitatively over an acidic range as a function of several formulation variables.
Monomer sequence in PLGA microparticles: Effects on acidic ...
2018年1月1日 · In this report, we utilize a sequence-control strategy to tailor the microstructure of PLGA. The internal acidic microclimate distributions within sequence-defined and random PLGA microparticles were monitored in vitro using a non-invasive ratiometric two-photon microscopy (TPM) methodology.
Visual Evidence of Acidic Environment Within Degrading Poly(lactic …
To quantitatively determine the intrapolymer acidity, weentrapped pH-sensitive fluorescent dyes (conjugated to 10,000 Dadextrans) within the microspheres and imaged them with confocalfluorescence microscopy. The technique allows visualization of thespatial and temporal distribution of pH within the degradingmicrospheres (1). Results.
Mapping microclimate pH distribution inside protein-encapsulated PLGA …
2012年5月5日 · The pH in the aqueous pores of poly(lactide-co-glycolide) (PLGA) matrix, also referred to microclimate pH (μpH), is often uncontrolled ranging from highly acidic to neutral pH range. The μpH distribution inside protein-encapsulated PLGA microspheres was quantitatively evaluated using confocal laser scanning microscopy.
Acidic Microclimate pH Distribution in PLGA Microspheres
2008年7月12日 · The acidic microclimate pH (µpH) distribution inside poly(lactic-co-glycolic acid) (PLGA) microspheres was monitored quantitatively as a function of s
poly(lactic-co-glycolic acid) (PLGA) microparticles in a robust high-throughput manner. This work contributes to the complex narrative of PLGA microparticle behavior and release...
Advanced PLGA hybrid scaffold with a bioactive PDRN/BMP2
2021年12月8日 · PLGA has been reported that its degradation byproducts, lactic acid and glycolic acid during hydrolysis after implantation, cause an acidic microenvironment (10).
Acidic microclimate pH distribution in PLGA microspheres
Effects of PLGA molecular weight (MW) and lactic/glycolic acid ratio, microspheres size and preparation method, and polymer blending with poly(ethylene glycol) (PEG) were evaluated. Results: micropH kinetics was accurately sensed over a broadly acidic range (2.8 < micropH < 5.8) and was more acidic and variable inside PLGA with lower MW and ...
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