Estrogen - Wikipedia
Estrogen (also spelled oestrogen in British English; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics.
The structural biology of oestrogen metabolism - PMC
Many enzymes catalyse reactions that have an oestrogen as a substrate and/or a product. The reactions catalysed include aromatisation, oxidation, reduction, sulfonation, desulfonation, hydroxylation and methoxylation. The enzymes that catalyse these reactions must all recognise and bind oestrogen but, despite this, they have diverse structures.
Estrogen Hormone Biology - PMC - PubMed Central (PMC)
Estrogen works through its two distinct nuclear receptors, Estrogen Receptor alpha (ERα) and Estrogen Receptor beta (ERβ). Various transcriptional regulation mechanisms have been identified as the mode of action for estrogen, mainly the classical mechanism with direct DNA binding but also a non-genomic mode of action and one using tethered or ...
History of Estrogen: Its Purification, Structure, Synthesis, Biologic ...
2018年12月18日 · Sophisticated biochemical methods revealed the mechanisms of estrogen synthesis through the enzyme aromatase and, after discovery of the estrogen receptors, their specific biologic actions. Molecular techniques facilitated understanding of the specific transcriptional and translational events requiring estrogen.
Estradiol - Wikipedia
Estradiol (E2), also called oestrogen, oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of female reproductive cycles such as estrous and menstrual cycles.
The structural biology of oestrogen metabolism - ScienceDirect
2013年9月1日 · There is one crystal structure of human CYP 1A2, PDB code 2HI4 [113], and one of CYP 1B1, PDB code 3PM0 [114]. The structure of both is based on that of the canonical P450 fold – twelve α-helices and four β-sheets, designated A-L and 1–4, respectively – with a few additional helices.
Estrogen receptor signaling mechanisms - PMC
Estrogen receptors regulate a multitude of biological and physiological processes. These are tightly controlled by complex mechanisms involving either genomic nuclear direct binding to specific DNA sequences, or activation of intracellular …
Estrone | C18H22O2 | CID 5870 - PubChem
Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione.
Estrogen Hormone Biology - PubMed
Estrogen works through its two distinct nuclear receptors, estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). Various transcriptional regulation mechanisms have been identified as the mode of action for estrogen, mainly the classical mechanism with direct DNA binding but also a nongenomic mode of action and one using tethered or ...
The structural biology of oestrogen metabolism - PubMed
The enzymes that catalyse these reactions must all recognise and bind oestrogen but, despite this, they have diverse structures. This review looks at each of these enzymes in turn, describing the structure and discussing the mechanism of the catalysed reaction.