Metronidazole - StatPearls - NCBI Bookshelf
2023年6月26日 · The mechanism of action of metronidazole occurs through a four-step process. Step one is the entry into the organism by diffusion across the cell membranes of anaerobic and aerobic pathogens. However, antimicrobial effects are limited to anaerobes. [6]
Metronidazole: Uses, Interactions, Mechanism of Action
Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. 14 It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections. 4,5 Metronidazole has been used as an antibiotic for several decades 15, with added antiparasitic ...
Metronidazole: An overview - UpToDate
2022年12月1日 · Metronidazole is one of the mainstay drugs for the treatment of anaerobic infections . It is approved by the US Food and Drug Administration for the treatment of anaerobic and protozoal infections. Metronidazole exerts its antimicrobial effects through the production of free radicals that are toxic to the microbe.
Metronidazole - Wikipedia
Metronidazole is primarily used to treat: bacterial vaginosis, pelvic inflammatory disease (along with other antibacterials like ceftriaxone), pseudomembranous colitis, aspiration pneumonia, rosacea (topical), fungating wounds (topical), intra-abdominal infections, lung abscess, periodontal disease, amoebiasis, oral infections, giardiasis, trich...
Metronidazole: Mechanism, Activity, Pharmacokinetics, and …
2024年10月23日 · Explore the comprehensive insights into metronidazole's mechanism, activity spectrum, pharmacokinetics, and potential drug interactions. Metronidazole is a widely used antimicrobial agent, effective against anaerobic bacteria and certain protozoa.
Metronidazole | C6H9N3O3 | CID 4173 - PubChem
Metronidazole is a member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension.
Metronidazole - ScienceDirect
1988年5月1日 · Metronidazole is active against the anaerobic protozoa Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia, and Balantidium coli. Some strains of T. vaginalis recently have been reported to be resistant,30 but the extent of this is not known.
Metronidazole - an overview | ScienceDirect Topics
Metronidazole is bactericidal against obligate anaerobes (MIC ranging from 0.25 to 8 μg/mL) and is protozoacidal against numerous protozoa with an in vitro MIC of ≤1 μg/mL. 60 The antimicrobial action of metronidazole targets DNA synthesis, in that metronidazole acts as an electron acceptor in the phosphoroclastic reaction and causes breaks ...
Metronidazole - PubMed
Metronidazole is one of the mainstay drugs for the treatment of anaerobic bacterial infections, protozoal infections, and microaerophilic bacterial infections. It is cytotoxic to facultative anaerobic microorganisms. It is used to treat intestinal amebiases, liver amebiasis, bacterial septicemia, bo …
Metronidazole: Mechanisms, Uses, and Resistance in Infections
2024年10月16日 · Metronidazole is an antimicrobial agent used to treat various infections. Its efficacy against anaerobic bacteria and certain protozoa makes it essential in modern medicine. The drug is indispensable for treating conditions like bacterial vaginosis, trichomoniasis, and infections caused by Helicobacter pylori.