Sensory neurons promote immune homeostasis in the lung - Cell …
2023年12月21日 · Employing a variety of different chemical, genetic, and viral neuronal manipulation approaches, we found that sensory neuron-intrinsic expression of murine Jak1 or …
Identification of lung innervating sensory neurons and their target ...
2021年12月22日 · Lung Innervating Sensory Neurons Reside Primarily in Vagal Ganglia and Project to the nTS Region of the Brainstem. To determine the location of lung innervating …
Brainstem Dbh + neurons control allergen-induced airway
2024年7月10日 · Here we mapped a full allergen circuit from the lung to the brainstem and back to the lung. Repeated exposure of mice to inhaled allergen activated the nuclei of solitary tract …
Neuronal Regulation of Immunity in the Skin and Lungs
We highlight recent studies showing roles for lung-innervating neurons in regulating immune cell function in asthma, chronic obstructive pulmonary disorder (COPD), and lung infections. …
Vagal Afferent Innervation of the Airways in Health and Disease
Vagal sensory neurons constitute the major afferent supply to the airways and lungs. Subsets of afferents are defined by their embryological origin, molecular profile, neurochemistry, …
Sensory neurons regulate stimulus-dependent humoral immunity …
2024年10月16日 · Our data, thus demonstrate that sensory neurons release select neuropeptides which target B cells dependent on the immunogen. The lung risks exposure to atmospheric …
Janus kinase 1 signaling exerts distinct effects across cell types and tissues, with JAK1 signaling in vagal sensory neurons promoting anti-inflammatory responses in the lung. Cytokines …
Vagal Sensory Neuron Subtypes that Differentially Control Breathing
2015年4月23日 · Breathing is essential for survival and under precise neural control. The vagus nerve is a major conduit between lung and brain required for normal respiration. Here, we …
Nociceptor sensory neurons suppress neutrophil and γδ T cell
2018年3月5日 · Targeted TRPV1 +-neuron ablation increased survival, cytokine induction, and lung bacterial clearance. Nociceptors suppressed the recruitment and surveillance of …
Identification of lung innervating sensory neurons and their …
2022年1月1日 · Here, we interrogated the cell body location and molecular signature and projection pattern of lung innervating sensory neurons. Retrograde tracing from the lung …