Interferon type I - Wikipedia
The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses.
Mechanisms of type-I- and type-II-interferon-mediated signalling …
2005年5月1日 · There are two main classes of interferon (IFN): type I IFNs and type II IFN. There are many type I IFNs, including IFN-α, IFN-β and IFN-ω, and all of these bind a common cell-surface...
Type I interferons in infectious disease - Nature
2015年1月23日 · Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the induction...
Interferon Type I - an overview | ScienceDirect Topics
The type I interferons are a group of cytokines consisting of a several related alpha interferon molecules and a single interferon beta protein, that are induced in response to stimuli associated with viral infections, such as double stranded RNA, and which bind to a common type I interferon receptor complex.
Type I Interferons as Regulators of Human Antigen Presenting …
Type I interferons (IFNs) are pleiotropic cytokines, initially described for their antiviral activity. These cytokines exhibit a long record of clinical use in patients with some types of cancer, viral infections and chronic inflammatory diseases.
The type I interferonopathies: 10 years on - Nature
2021年10月20日 · The term ‘type I interferonpathy’ was coined 10 years ago to describe rare genetic diseases that are caused by an aberrant upregulation of type I interferon signalling.
The Type I Interferonopathies - PubMed
2017年1月14日 · Type I interferons (IFNs) play a central role in the immune defense against viral infections. Type I IFN activation is induced by pattern-recognition receptors of the innate immune system that sense pathogen-derived nucleic acids. Cellular responses to type I IFN signaling are orchestrated by a comp …
The type I interferons: Basic concepts and clinical relevance in …
2016年1月15日 · In this review, we cover some general aspects of type I interferon genes, with emphasis on interferon-alpha, and various aspects of molecular mechanisms triggered by type I interferons and toll-like receptor signaling by the Janus activated kinase/signal transducer activation of transcription (JAK–STAT) pathway and interferon regulatory ...
Overview of the biology of type I interferons - PMC - PubMed …
Type I interferons are pleiotropic cytokines with antiviral, antitumor and immunoregulatory functions. An aspect of their complex biology is the paradox that, depending on context, type I interferons can be anti-inflammatory and tissue protective or …
Type I Interferons in Autoimmunity: Implications in Clinical …
2023年9月1日 · Type I interferon (IFN-I) is thought to play a role in many systemic autoimmune diseases. IFN-I pathway activation is associated with pathogenic features, including the presence of autoantibodies and clinical phenotypes such as more severe disease with increased disease activity and damage.