A minimalist multifunctional nano-prodrug for drug resistance …
16 小时之前 · To confirm the function of nano-prodrug in IDO and SLC7A11 expression, we initially performed a Western blot assay to analyze the levels of these two signaling proteins. As expected, the IDO expression was downregulated in Hepa1-6/FU cells treated with FU-SS-IND NPs (Fig. 4b). The expression of SLC7A11 was also assessed by Western blot under ...
A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3 …
Expression of indoleamine-2,3-dioxygenase (IDO), an immunosuppressive enzyme in human tumors, leads to immune evasion and tumor tolerance. IDO is therefore a tumor immunotherapeutic target, and several IDO inhibitors are currently undergoing clinical trials. IDO inhibitors can enhance the efficacy of common cancer chemotherapeutics.
Combination of IDO inhibitors and platinum(IV) prodrugs reverses …
2023年6月1日 · Herein, we designed composite nanoparticles (NP–Pt-IDOi) from a reactive oxygen species (ROS) sensitive amphiphilic polymer (PHPM) with thiol-ketal bonds in the main chain to encapsulate a Pt (IV) prodrug (Pt (IV)–C12) and an indoleamine- (2/3)-dioxygenase (IDO) inhibitor (IDOi, NLG919).
A Platinum(IV) Pro-drug Preferentially Targets IDO Providing …
Expression of indoleamine-2,3-dioxygenase (IDO), an immunosuppressive enzyme in human tumors, leads to immune evasion and tumor tolerance. IDO is therefore a tumor immunotherapeutic target, and several IDO inhibitors are currently undergoing clinical trials. IDO inhibitors can enhance the efficacy of common cancer chemotherapeutics.
A prodrug nanoplatform via esterification of STING agonist and IDO ...
2022年6月29日 · We synthesized the TME responsive prodrug by coupling MSA-2, a stimulator of interferon genes (STING) agonist, and NLG-919, an indoleamine 2,3 dioxygenase (IDO) inhibitor. The prodrug was assembled into nanoparticles to enhance the solubility and bioavailability.
Light‐Triggered PROTAC Nanoassemblies for Photodynamic IDO …
2024年6月19日 · We herein propose a light-triggered PROTAC nanoassembly (LPN) for photodynamic IDO proteolysis, linking the photosensitizer verteporfin (VPF) to an IDO-targeting PROTAC through a cathepsin-B (Cat-B)-specific cleavable peptide, KRR (Scheme 1A).
Semiconducting polymer nano-PROTACs for activatable photo
2021年5月18日 · Indoleamine 2,3-dioxygenase (IDO) is selected as the POI for PROTAC, because it is a Trp-catabolizing enzyme overexpressed in tumor tissues that converts Trp...
Self-driven nanoprodrug platform with enhanced ferroptosis for ...
Here, we report a multifunctional nanoprodrug platform with self-driven indoximod (IND) release and oxidative stress amplification. The aim is to awaken immune responses and block the indoleamine 2,3-dioxygenase (IDO) pathway through a combination of ferroptosis, photothermal therapy, and immunotherapy.
A prodrug nanoplatform via esterification of STING agonist and IDO ...
2022年6月29日 · We synthesized the TME responsive prodrug by coupling MSA-2, a stimulator of interferon genes (STING) agonist, and NLG-919, an indoleamine 2,3 dioxygenase (IDO) inhibitor. The prodrug was...
Tumor microenvironment-responsive prodrug nanoplatform via …
2020年6月1日 · The prodrug nanoplatform is performed by integrating PEGylated indoleamine-2,3-dioxygenase (IDO) inhibitor (Epacadostat) and photosensitizer (Indocyanine green, ICG) into a core-shell nanostructure via intermolecular interactions, which can transform into small dual-drug complexes (<40 nm) at tumor microenvironment.