Histone acetyltransferase - Wikipedia
Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine. DNA is wrapped around histones, and, by transferring an acetyl group to the histones, genes can be turned on and off.
Histone acetyltransferases - PubMed
This review discusses our current understanding of histone acetyltransferases (HATs) or acetyltransferases (ATs): their discovery, substrate specificity, catalytic mechanism, regulation, and functional links to transcription, as well as to other chromatin-modifying activities.
Histone Acetyltransferase - an overview | ScienceDirect Topics
Histone Acetyltransferases (HATs) are enzymes that modify histone proteins by adding an acetyl group to conserved lysine residues. This modification disrupts the interaction between DNA and histone tails, leading to changes in gene expression.
Histone Acetyltransferases - Annual Reviews
This review discusses our current understanding of histone acetyltransferases (HATs) or acetyltransferases (ATs): their discovery, substrate specificity, catalytic mechanism, regulation, and functional links to transcription, as well as to other chromatin-modifying activities.
Writers and Readers of Histone Acetylation: Structure, …
Histone acetyltransferases (HATs), sometimes referred to as lysine acetyltransferases or KATs, form a superfamily of enzymes that acetylate the side-chain amino group of lysine residues on histones, and in some cases also other proteins.
The Role of Histone Acetyltransferases in Normal and Malignant ...
Histone acetyltransferases (HATs), which are the enzymes responsible for histone and non-histone protein acetylation, contain p300/CBP, MYST, and GNAT family members. HATs are not only protein modifiers and epigenetic factors but also critical regulators of …
Histone acetyltransferase complexes: one size doesn't fit all
Histone acetyltransferases (HATs) are highly diverse multiprotein complexes that carry out diverse functions, ranging from repairing regions of DNA damage to maintaining overall genomic...
Histone acetyltransferases: challenges in targeting bi-substrate ...
2016年5月26日 · Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors, and enzymes. HATs have been shown to play a role in diseases ranging from cancer and inflammatory diseases to neurological disorders, both through acetylations ...
Histone Acetyltransferase - an overview | ScienceDirect Topics
Histone acetyltransferases (HATs) are enzymes able to acetylate lysine side chains of histones. They play essential roles in normal cell function as well as in pathogenesis of a broad set of diseases, including multiple cancers, HIV, diabetes mellitus, and neurodegenerative disorders.
Structure and function of histone acetyltransferases - PMC
Histone acetyltranferase (HAT) enzymes are the catalytic subunit of large multisubunit HAT complexes that acetylate the ε -amino group of specific lysine residues on histone tails to promote transcriptional activation.