An atlas of healthy and injured cell states and niches in the human kidney
2023年7月19日 · We define niches for healthy and altered states across different regions of the human kidney spanning the cortex to the papillary tip, and identify gene expression and regulatory modules in ...
An atlas of healthy and injured cell states and niches in the human kidney
Understanding kidney disease relies on defining the complexity of cell types and states, their associated molecular profiles and interactions within tissue neighbourhoods 1. Here we applied multiple single-cell and single-nucleus assays (>400,000 nuclei or cells) and spatial imaging technologies to a broad spectrum of healthy reference kidneys ...
New atlas of human kidney cells to help unlock kidney disease …
2023年7月19日 · Data from the Kidney Tissue Atlas will allow the comparison of healthy kidney cells to those injured by kidney disease, helping investigators understand the factors that contribute to the progression of kidney disease and kidney failure or recovery from injury.
Kidney Tissue Atlas
The Kidney Tissue Atlas is a set of interactive tools built to promote retrieval, exploration, discovery, and analysis of the KPMP data by the greater research community. Learn more about our data types and methodologies. Search for markers or cell types of interest and view summary data visualizations across the various KPMP 'omics' technologies.
Detailed “kidney atlas” characterizes cells of the healthy adult kidney
This atlas delineates the biology of individual cells in various parts of the nephron and its surrounding tissue, demonstrating how they are defined not only by their position in the kidney, but also by the precise molecular signatures of genes and proteins active within them.
A reference tissue atlas for the human kidney | Science Advances
2022年6月8日 · Kidney Precision Medicine Project (KPMP) is building a spatially specified human kidney tissue atlas in health and disease with single-cell resolution. Here, we describe the construction of an integrated reference map of cells, pathways, and genes using unaffected regions of nephrectomy tissues and undiseased human biopsies from 56 adult subjects.
Kidney Histology, Kidney Function, and Age - American Journal of Kidney …
2021年1月13日 · In summary, the study by Li et al represents an important contribution to the literature, as the findings highlight the relationship between kidney histology, kidney function, and age in a population selected on neither good health …
Single-cell profiling of healthy human kidney reveals features of …
2022年12月10日 · We provide a map of healthy human kidney using single-cell RNA sequencing (scRNAseq) of 19 living donors, capturing parenchymal and immune cell transcriptomes reflective of a healthy state....
Single-cell multi-omic and spatial profiling of human kidneys ...
2024年7月24日 · Here we present the spatial molecular principles of kidney health and disease by generating a comprehensive and spatially resolved human kidney atlas and combining single-cell omics data...
The kidney—more than the sum of its cellular parts
2022年8月30日 · The Kidney Tissue Atlas is accessible via https://atlas.kpmp.org/ and currently holds data from scRNA-seq as well as spatial transcriptomics of healthy kidney tissue and selected cohorts of patients with chronic kidney disease and acute kidney injury (AKI). 3 Next to transcriptomics data, also information on a set of protein markers from Co ...