Pathology Outlines - Gout and gouty arthritis
2023年1月11日 · Histology showed nodular aggregates consisting of acellular, amorphous, pale eosinophilic material surrounded by palisading arrangement of histiocytes and multinucleated giant cells. The material showed needle-like crystals which appeared brightly anisotropic under polarized light. What is the most likely diagnosis?
Gout : Histology - WebPathology
In formalin-fixed tissues, gouty tophi appear as large amorphous deposits in the dermis and subcutaneous tissues surrounded by granulomatous inflammation and foreign body giant cells.
Gout - Libre Pathology
Gout is a common benign affliction that can be disabling. It occasionally is seen by pathologists. It can be grouped in conditions with crystals in body fluids. Classically afflicts the big toe - known as podagra. Epidemiology: [1] Male (Females relative risk ~ …
Cytodiagnosis of gouty tophus - PMC - National Center for …
2013年5月29日 · On histology, gouty tophus shows large amorphous aggregates of urate crystals surrounded by intense inflammatory cells macrophages, lymphocytes, foreign body giant cells, and fibroblastic reaction. However, the morphology of individual crystals …
Gout : Histology - WebPathology
High power view of gouty tophi which are large aggregates of monosodium urate crystals surrounded by an intense inflammatory reaction consisting of foreign body giant cells, histiocytes, and lymphocytes.
The anatomical pathology of gout: a systematic literature review
2019年4月1日 · Typically, the clinical course of gout includes asymptomatic hyperuricemia, intermittent attacks (flares) of acute arthritis, intercritical gout, and, if hyperuricaemia is untreated, advanced gout, characterized clinically by tophi, chronic gouty arthritis and …
Webpathology.com: A Collection of Surgical Pathology Images
Locations where gouty tophi can be seen include the joints, ligaments, tendons, peri-articular soft tissues, bursae, and less frequently in earlobes, nasal cartilages, kidneys, and skin of fingertips. Monosodium urate crystals are best visualized in alcohol-fixed tissues as long, needle-shaped negatively birefringent crystals.
Histopathologic Examination of Conjunctival Tophi in Gouty …
2005年12月1日 · Analysis of biopsy revealed multiple tophi composed of eosinophilic material surrounded by histiocytes and foreign body giant cells, indicating tophaceous gout (hematoxylin and eosin, magnification ×25).
[Histopathophysiology of Gout] - PubMed
Bone erosions in gout occur around tophi and are triggered by osteoclast activation through RANK-ligand expression by lymphocytes. In conclusion, understanding the orchestration of inflammation in gout might help to identify new therapeutic targets.
The Gouty Tophus: a Review | Current Rheumatology Reports
2015年3月12日 · The tophus is the cardinal feature of advanced gout. This review summarises recent research into the biology, impact and treatment of tophaceous gout. Microscopically, tophi are chronic foreign body granuloma-like structures containing collections of monosodium urate (MSU) crystals surrounded by inflammatory cells and connective tissue.