Pathology Outlines - Gout and gouty arthritis
2 天之前 · Gout is a metabolic condition associated with hyperuricemia. It can be primary (sporadic or familial) or secondary. Clinical and serological correlation with serum uric acid levels is recommended. A 58 year old man presented with painful foot swelling.
Gout - StatPearls - NCBI Bookshelf
2019年11月30日 · Gout is one of the most common causes of chronic inflammatory arthritis in the United States, characterized by monosodium urate (MSU) monohydrate crystals deposition in the tissues. Gout was first recognized even before the common era. Hence, it is arguably the most understood and manageable disease among other rheumatic diseases.
Pathophysiology and Treatment of Gout Arthritis; including Gout ...
The aim of this review is to provide an overview of the pathophysiology of gout and subsequently examine current diagnostic methods and therapeutic agents for treatment of gout, based on an understanding of its underlying mechanisms.
Gout: An old disease in new perspective – A review - PMC
Gout is a picturesque presentation of uric acid disturbance. It is the most well understood and described type of arthritis. Its epidemiology is studied. New insights into the pathophysiology of hyperuricemia and gouty arthritis; acute and chronic allow for …
Clinicians treating patients with gout need to prevent the development of chronic, destructive arthritis and the overt, large tophaceous deposits of advanced gout. Over time, even in the absence of flares, deposited crystals and inflammation can lead to the development of clinically evident joint damage and erosions that can be seen on
An update on the pathology and clinical management of gouty arthritis
Gouty arthritis is an inflammatory condition associated with debilitating clinical symptoms, functional impairments, and a substantial impact on quality of life. This condition is initially triggered by the deposition of monosodium urate crystals into the joint space.
Pathophysiology | Gout - U.OSU
Gout = inflammatory response to excess amounts of uric acid (UA) in the body resulting in acute attacks of arthritis. UA = byproduct of purine metabolism, normally excreted by kidneys. At low levels, UA = important antioxidant; At higher levels, UA = pro-oxidant, pro-inflammatory
Molecular Pathophysiology of Gout - ScienceDirect
2017年8月1日 · Acute gouty arthritis is a paradigmatic example of the crescendo and decrescendo of crystal-induced necroinflammation. Understanding the role of IL-1 in the molecular pathogenesis of gout has raised the possibility of using IL-1-targeting drugs as a novel treatment option for patients with recurrent gout.
Pathophysiology of Gout - ScienceDirect
2020年11月1日 · Gout is the most common cause of inflammatory arthritis and its prevalence is increasing worldwide. 1 Clinically, gout is characterized by episodes of severe joint inflammation, interspersed with symptom-free intercritical periods. Without urate-lowering therapy, advanced gout can develop and is characterized by tophaceous disease and ...
Pathophysiology of gout - UpToDate
2024年5月24日 · Gout is a disease that occurs in response to the presence of monosodium urate (MSU) crystals in joints, bones, and soft tissues. It may result in one or a combination of acute arthritis (a gout flare), chronic arthritis (chronic gouty arthritis), and tophi (tophaceous gout) .