DAF-16/FOXO employs the chromatin remodeller SWI/SNF to …
We now established DAF-16/FOXO-controlled stress-responsive and lifespan-regulatory roles for a type of chromatin alteration fundamentally distinct from epigenetic changes, namely ATP-dependent chromatin remodelling at the hands of SWI/SNF.
Transcriptional memory of dFOXO activation in youth curtails
2022年12月1日 · This youth-restricted dFOXO activation causes persistent changes to chromatin landscape in the fat body and requires chromatin remodelers such as the SWI/SNF and ISWI complexes to program...
Age-Dependent Changes in Transcription Factor FOXO Targeting …
2019年5月7日 · Our analysis also revealed that FOXO targets chromatin organization and nucleosome assembly processes. This finding suggests that FOXO may be involved in the maintenance of chromatin structure. Recent studies have shown that FOXO recruits SWI/SNF chromatin remodelers to specific target sites to regulate lifespan in C. …
FOXO transcription factors as mediators of stress adaptation
2023年9月14日 · Binding of the acetyltransferase p300 or its homologue CREB-binding protein (CBP) to FOXO can, on the one hand, facilitate histone tail acetylation and opening of the chromatin and allow for...
Genome-wide analysis of FoxO1 binding in hepatic chromatin: …
We globally identified FoxO1 occupancy in mouse hepatic chromatin on a genome-wide level by chromatin immunoprecipitation coupled with high-throughput DNA sequencing (ChIP-seq). To establish the specific functional significance of FoxO1 against other FoxO proteins, ChIP-seq was performed with chromatin from liver-specific FoxO1 knockout and ...
Genome-wide analysis of FoxO1 binding in hepatic chromatin ... - PubMed
The forkhead transcription factor FoxO1 is a critical regulator of hepatic glucose and lipid metabolism, and dysregulation of FoxO1 function has been implicated in diabetes and insulin resistance. We globally identified FoxO1 occupancy in mouse hepatic chromatin on a genome-wide level by chromatin i …
FoxO transcription factors actuate the formative pluripotency …
2024年9月9日 · Our work uncovers a pivotal role for FoxO TFs in establishing formative post-implantation pluripotency, a critical early embryonic cell fate transition. Pluripotent cells can give rise to all...
Chromatin opening and stable perturbation of core histone:DNA …
2007年12月7日 · FoxO1, a member of the forkhead rabdomyosarcoma (FoxO) subfamily of transcription factors, binds DNA via a highly conserved winged-helix "forkhead box" motif used by other regulatory proteins to mediate their effects through chromatin binding and remodeling. To examine how FoxO1 regulates target gen …
FOXO1 stimulates tip cell-enriched gene expression in endothelial …
2024年3月15日 · Endogenous FOXO1 ChIP-seq revealed that FOXO1 binds to the EC-unique tip-enriched genes with co-enrichment of EC master regulators, and the condensed chromatin region as a pioneer factor. We identified new promoter/enhancer regions of the VEGF-responsive tip cell genes regulated by FOXO1: ESM1 and ANGPT2 .
Chromatin Opening and Stable Perturbation of Core
2007年12月7日 · This study, which implicates FoxO1 as a pioneer factor for gene activation in chromatin, provides the first demonstration of FoxO protein binding to extended and condensed chromatin structures. It is also the first to directly map chromatin-remodeling capabilities, other than chromatin opening, to amino acid sequences located outside the winged ...
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