Ectodomain - Wikipedia
An ectodomain is the domain of a membrane protein that extends into the extracellular space (the space outside a cell). Ectodomains are usually the parts of proteins that initiate contact with surfaces, which leads to signal transduction .
Cell surface receptor - Wikipedia
The extracellular domain is just externally from the cell or organelle. If the polypeptide chain crosses the bilayer several times, the external domain comprises loops entwined through the membrane. By definition, a receptor's main function is to …
Ectodomain - an overview | ScienceDirect Topics
Ectodomain cleavage is the function of transmembrane ADAMs (a disintegrin and metalloprotease) and other membrane-bound metalloproteases, which have an extracellular catalytic domain. Almost all work on ectodomain cleavage regulation has focused on the control of enzyme activity determined by substrate cleavage as surrogate.
The Role of the Extracellular Domain in the Biology of the ...
2005年3月18日 · The extracellular domain of CAR is required for lateral localization in polarized airway epithelial cells. Primary HAE were infected with Ad-CAR, CAR D0, CAR ΔD1, or CAR ΔD2 and immunostained for the FLAG epitope (green), the tight junction protein ZO-1 …
A guide to the composition and functions of the extracellular …
2021年2月19日 · The extracellular domain, especially the αI domain, provides ligand specificity with several different ECM macromolecules or counter receptors on adjacent cell surfaces. There are four broadly grouped categories: (a) The arginine-glycine-aspartic acid, or RGD motif, (b) Laminin receptors, (c) Leukocyte-specific receptors, (d) Collagen ...
Extracellular domain - (General Biology I) - Vocab, Definition ...
The extracellular domain is the portion of a cell surface receptor that extends outside the cell. It interacts with signaling molecules, triggering intracellular responses.
Influence of the extracellular domain size on the dynamic …
2022年10月18日 · We studied how the size and glycosylation of the proteins influences their dynamic behavior in a lipid bilayer by reconstituting the extracellular domains (ECDs) of different sizes or glycosylation in model membrane systems and analyzing their sorting into lipid domains as well as their mobility.
Molecular and cellular mechanisms of ectodomain shedding
The extracellular domain of several membrane-anchored proteins is released from the cell surface as soluble proteins through a regulated proteolytic mechanism called ectodomain shedding. Cells use ectodomain shedding to actively regulate the expression and function of surface molecules, and modulate …
Domain structure and organisation in extracellular matrix proteins
2002年3月1日 · Extracellular matrix (ECM) proteins are large and multifunctional molecules. They are composed of many domains that frequently are repeated within the same molecule or show phylogenetic links to domains in other proteins. The multifunctional nature of ECM proteins is a direct reflection of their modular architecture.
Molecular Characterization of the Extracellular Domain of Human ...
2021年3月27日 · Here, we present such a study, where through maltose-binding protein (MBP) fusion strategies we have purified all extracellular domains of the TJ’s JAM proteins. This strategy enabled yields of sufficient quantities of material for protein–protein interactions studies, circular dichroism and surface plasmon resonance.