Excitatory Projection Neuron Subtypes Control the Distribution …
2011年2月24日 · In the mammalian cerebral cortex, the developmental events governing the integration of excitatory projection neurons and inhibitory interneurons into balanced local circuitry are poorly understood. We report that different subtypes of projection neurons uniquely and differentially determine the laminar distribution of cortical interneurons.
Early cortical GABAergic interneurons determine the projection …
2024年5月10日 · During cerebral cortex development, excitatory pyramidal neurons (PNs) establish specific projection patterns while receiving inputs from GABAergic inhibitory interneurons (INs). Whether these inhibitory inputs can shape PNs’ projection patterns is, however, unknown.
High-throughput mapping of single-neuron projection and
2024年2月23日 · Combining with single neuron transcriptome, we explored the transcriptome and subtype composition of vmPFC neurons projecting to different downstream brain regions. We first re-clustered excitatory projection neurons expressing Slc17a7 (also known as vesicular glutamate transporter, Vglut1).
A direct excitatory projection from entorhinal layer 6b ... - Nature
2022年8月16日 · The mammalian hippocampal formation plays a key role in several higher brain functions. Here, the authors show that excitatory neurons in layer 6b of the mouse EC project to all sub-regions ...
Pinpointing Morphology and Projection of Excitatory Neurons in …
2019年8月28日 · To pinpoint the excitatory neurons in the visual cortex, it is timely to study their complete morphology, neuron types and corresponding projection patterns. Here, we applied the brain-wide positioning system (BPS) (Gong et al., 2016) to obtain volumetric imaging of the whole mouse brain dataset with a resolution of 0.2 μm × 0.2 μm × 1 μm.
Neuronal subtype specification in the cerebral cortex
Projection neurons are glutamatergic neurons characterized by a typical pyramidal morphology, and function to transmit information both between different regions of the cortex and to other...
Spatially patterned excitatory neuron subtypes and projections …
2021年8月16日 · This research presents a novel optical intervention strategy with terahertz waves for the treatment of NP and holds promising applications in other nervous system diseases. The claustrum comprises spatially patterned excitatory neuron subtypes with distinct molecular and projection properties.
The cell-type underpinnings of the human functional cortical
2 天之前 · In cluster 5, vasoactive intestinal polypeptide-expressing interneuron (VIP), layer 6 intratelencephalic-projecting excitatory neuron (L6 IT) and layer 6 corticothalamic-projecting excitatory ...
Cultured networks of excitatory projection neurons and …
2016年4月6日 · In summary, we report a robust and easily reproducible system for generation of excitatory projection neurons and inhibitory interneurons. These human cortical neurons can be used to study the mechanisms of excitotoxicity and …
Neuronal subtypes and diversity revealed by single-nucleus RNA ...
2016年6月24日 · Both excitatory and inhibitory neuronal subtypes show regional variations that define distinct cortical areas and exhibit how gene expression clusters may distinguish between distinct cortical areas. This method opens the door to widespread sampling of the genes expressed in a diseased brain and other tissues of interest.