Pathology Outlines - CD71
2021年5月14日 · CD71 is an integral membrane protein that mediates the uptake of transferrin iron complexes In human tissues, CD71 is more highly expressed in placental syncytiotrophoblast, myocytes, hepatocytes, basal keratinocytes, endocrine cells of the pancreas, spermatocytes and erythroid precursors
Pathology Outlines - Megaloblastic anemia
2022年7月13日 · Bone marrow aspirate: Adequate for evaluation. Bone marrow aspirate smear is hypercellular with erythroid hyperplasia, reversal of M:E ratio (1:5). Erythroid precursors show megaloblastic changes, nuclear budding and nuclear irregularity. Myeloid lineage cells are reduced in number. Giant metamyelocytes are seen. Neutrophils show hypersegmentation.
Pathology Outlines - Primary myelofibrosis
2024年10月31日 · The marrow aspirate smears are spicular and cellular. Megakaryocytes are increased and show prominent dysmegakaryopoiesis, including hyper and hyposegmented nuclei and increased N:C ratio. The myeloid:erythroid ratio is approximately 4:1. Erythroid maturation is identified. Myeloid maturation is slightly left shifted.
Pathology Outlines - AML with maturation (FAB AML M2)
2013年2月1日 · Erythroid and megakaryocyte precursors may have dysplastic changes Often increased eosinophilic precursors without cytological and cytochemical abnormalities of inv(16)(p13.1q22) Basophils may be increased, rarely mast cell hyperplasia ( Indian J Pathol Microbiol 2007;50:655 )
Pathology Outlines - CD117
2022年6月9日 · Proto-oncogene activated in GISTs (Cureus 2022;14:e20868) Gene at 4q11-21 Class III receptor tyrosine kinase
Pathology Outlines - Chronic myelomonocytic leukemia
2024年3月6日 · Hematopoiesis: trilineage maturation with myelomonocytic hyperplasia and relative erythroid hypoplasia. Megakaryocytes are increased (15/high power field on average) and are dysplastic (pleomorphic increased small or hypolobated forms, many with hyperchromatic nuclei, rarely with separation of nuclear lobes.
Pathology Outlines - Parvovirus (erythrovirus) B19
2006年12月1日 · Chronic parvovirus infection: associated with immunodeficiency, erythroid hyperplasia, numerous inclusions, particularly in basophilic and polychromatic erythroblasts Case reports Newborn with leukoerythroblastosis ( Haematologica 2005;90:ECR38 )
Pathology Outlines - Pure red cell aplasia
2013年9月1日 · Anti-erythroid antibodies may be detected in some patients Also due to allogeneic bone marrow transplant from ABO incompatible donor (treat with aggressive plasmapheresis) May be due to antibodies to recombinant erythropoietin in those with chronic renal failure
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Pathology Outlines - Features to report
2006年12月1日 · Erythroid cell: Normal or abnormal maturation. Provide differential of myeloid and erythroid elements, based on counting 200 - 500 cells in aspirate smear Megakaryocytes: Normal or abnormal numbers and morphology. Lymphocytes: Lymphoid aggregates Hematogones Other abnormalities. Plasma cells: Normal or …