The Amygdala and Depression: A Sober Reconsideration - PMC
Tamm and colleagues’ report serves as a sober reminder that simple box-and-arrow neurobiological explanations—which equate amygdala hyper-reactivity with depression independent of clinical presentation, severity, disease stage, developmental period, adversity exposure, imaging technique, and fMRI paradigm—are no longer tenable.
The Amygdala and Depression: A Sober Reconsideration
2022年7月1日 · Tamm and colleagues’ report serves as a sober reminder that simple box-and-arrow neurobiological explanations—which equate amygdala hyperreactivity with depression independent of clinical presentation, severity, disease stage, developmental period, adversity exposure, imaging technique, and fMRI paradigm—are no longer tenable.
Blunted Amygdala Activity is Associated with Depression …
These findings suggest that MDD is characterized by abnormal amygdala activation to affective stimuli that is influenced by depression severity. Amygdala activation to emotional stimuli can attenuate following the treatment of depression using selective serotonin reuptake inhibitors (SSRIs) (Delaveau et al., 2011; Sheline et al., 2001) or ...
Brain changes in depression - PMC - PubMed Central (PMC)
In depression there are hyperactivity in the amygdala, striated nucleus, limbic and subcortical regions. Not only antidepressants but also psychotherapy can alter the functionality of the brain. Neurons have their own ability to change their power in …
The Amygdala and Depression: A Sober Reconsideration
Keywords: Depressive Disorders; Neuroimaging; amygdala; depression; fMRI; internalizing disorders; major depressive disorder (MDD).
Persistence of amygdala hyperactivity to subliminal negative …
2024年1月26日 · Neuroimaging studies have shown mood-congruent alterations in amygdala activity in patients with acute depression, even during early, automatic stages of emotion processing.
Amygdala substructure volumes in Major Depressive Disorder
2021年1月1日 · The amygdala, tightly nestled on top of and densely interconnected with the hippocampus, plays an essential role in emotional processing, affective/mood state, fear conditioning and extinction and social behaviours (Fox and Shackman, 2019, Hur et al., 2019, Janak and Tye, 2015, Lindquist et al., 2012, Putnam and Chang, 2021, Shackman et al., 2016).
Amygdala’s role in treatment-resistant depression - Nature
2023年5月10日 · Evidence suggests that DBS that targets the ventral anterior limb of the internal capsule (vALIC) — a brain structure that connects the frontal cortex with subcortical regions — reduces...
Deep brain stimulation normalizes amygdala responsivity in …
2023年3月29日 · Deep brain stimulation (DBS) of the ventral anterior limb of the internal capsule (vALIC) is a promising intervention for treatment-resistant depression (TRD). However, the working mechanisms...
Amygdala functional connectivity in major depression – disentangling ...
2019年10月22日 · Reduced resting-state amygdala FC with the right frontal cortex has been shown to be shared by adolescents with depression and at high risk for depression (Singh et al., Reference Singh, Leslie, Packer, Weisman and Gotlib 2018b). Together, this suggests a reduced task-independent integration of amygdala and executive control structures as risk ...