DNA Damage and DNA Repair: Types and Mechanism - Microbe …
2023年9月8日 · To overcome the harmful effects of DNA damage, cells have various systems such as DNA repair mechanisms, damage tolerance pathways, cell cycle checkpoints, and cell …
Mechanisms of DNA damage, repair and mutagenesis - PMC
In this introductory review, we will delineate mechanisms of DNA damage and the counteracting repair/tolerance pathways to provide insights into the molecular basis of genotoxicity in cells …
DNA damage (naturally occurring) - Wikipedia
DNA damage is an alteration in the chemical structure of DNA, such as a break in a strand of DNA, a nucleobase missing from the backbone of DNA, or a chemically changed base such as …
DNA damage repair: historical perspectives, mechanistic pathways and ...
2021年7月9日 · In this review, we first illustrate the timeline steps for the understanding the roles of DNA damage repair in the promotion of cancer and cancer therapy developed, then we …
Exploring DNA Damage and Repair Mechanisms: A Review with …
2024年1月24日 · DNA damage is a critical factor contributing to genetic alterations, directly affecting human health, including developing diseases such as cancer and age-related …
The central role of DNA damage in the ageing process - Nature
2021年4月28日 · The strong mechanistic link between DNA damage and ageing, and the role of DNA as the primary template for all cellular functions, suggest DNA damage as a candidate for …
DNA Damage & Repair: Mechanisms for Maintaining DNA Integrity
DNA is essential to life, but it is subject to damage from interaction with various chemicals and environmental agents. In addition, mutations arise each time DNA is replicated.
DNA Damage: From Threat to Treatment - PMC - PubMed …
In the first part of this review, we describe the critical processes encompassing DNA damage sensing and resolution. In the second part, we illustrate the consequences of partial or …
Genetics, DNA Damage and Repair - StatPearls - NCBI Bookshelf
2023年8月14日 · Unfortunately, the DNA is at constant risk of mutation, which means a change to the genetic information in a cell, and this can happen due to a variety of factors. [1] One must …
DNA Repair - Molecular Biology of the Cell - NCBI Bookshelf
Maintaining genetic stability requires not only an extremely accurate mechanism for replicating DNA, but also mechanisms for repairing the many accidental lesions that occur continually in …