Cyclosporin microemulsion (Neoral). A pharmacoeconomic review …
Cyclosporin microemulsion (Neoral) is a self-emulsifying preconcentrate of cyclosporin which is more rapidly and consistently absorbed than the original oil-based formulation of cyclosporin (standard formulation; Sandimmun, Sandimmune).
Microemulsion formulation of cyclosporin (Sandimmun Neoral
2000年2月1日 · To compare the safety, tolerability and efficacy of the new oral microemulsion formulation of cyclosporin A (CyA; Sandimmun Neoral ®) and the original CyA formulation (Sandimmun ®), in patients with severe active rheumatoid arthritis (RA), over a 12‐month period.
Neoral® is an oral formulation of cyclosporine that immediately forms a microemulsion in an aqueous environment. Cyclosporine, the active principle in Neoral®, is a cyclic polypeptide...
Neoral: a microemulsion cyclosporine - PubMed
Neoral, a new oral microemulsion formulation (in capsules and oral solution) of cyclosporine, improves the bioavailability and pharmacokinetics of cyclosporine and reduces inter- and intraindividual pharmacokinetic variability with a safety profile comparable to that of Sandimmune.
Cyclosporin Microemulsion (Neoral®)† | PharmacoEconomics
2012年12月3日 · Cyclosporin microemulsion (Neoral®) is a self-emulsifying preconcentrate of cyclosporin which is more rapidly and consistently absorbed than the original oil-based formulation of cyclosporin (standard formulation; Sandimmun®, Sandimmune ®).
Cyclosporin: an updated review of the pharmacokinetic ... - PubMed
Cyclosporin microemulsion is at least as effective as the oil-based formulation in renal, liver and heart transplant recipients, with trends towards decreased incidence of acute rejection with the microemulsion formulation in some (statistically significant in a few) trials.
Cyclosporin | Drugs - Springer
2012年10月13日 · This new formulation is a microemulsion preconcentrate which, on contact with gastrointestinal fluids, readily produces a microemulsion that mimics the mixed micellar phase of absorption seen with the standard oral formulation. The microemulsion system is stable, releases cyclosporin quickly, and can be diluted without causing precipitation.
Cyclosporine microemulsion increases drug exposure and …
1998年9月1日 · The new oral microemulsion formulation of cyclosporine (Neoral®) possesses superior pharmacokinetics to the conventional formulation, Sandimmun® (SIM), providing more complete and predictable absorption, and less pharmacokinetic variability.
Neoral: a microemulsion cyclosporine. - Semantic Scholar
1996年3月1日 · Neoral, a new oral microemulsion formulation (in capsules and oral solution) of cyclosporine, improves the bioavailability and pharmacokinetics of cyclosporine and reduces inter- and intraindividual pharmacokinetic variability with …
A New Microemulsion Formulation of Cyclosporin
2012年11月22日 · Recently, a new galenic formulation of cyclosporin was introduced, ‘Neoral’, which is a water-free microemulsion of cyclosporin. The microemulsion creates micelles which are absorbed in the small bowel without the presence of bile.