Complement system - Wikipedia
The complement system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. [1]
The complement system and innate immunity
Complement is a system of plasma proteins that can be activated directly by pathogens or indirectly by pathogen-bound antibody, leading to a cascade of reactions that occurs on the surface of pathogens and generates active components with various effector functions.
Complement System | British Society for Immunology
The complement system plays a critical role in inflammation and defence against some bacterial infections. Complement may also be activated during reactions against incompatible blood transfusions, and during the damaging immune responses that accompany autoimmune disease.
The complement system: history, pathways, cascade and inhibitors
2012年2月2日 · The complement system is an integral part of the innate immune response and acts as a bridge between innate and acquired immunity. It consists of a series of proteins that are mostly (although not exclusively) synthesised in the liver, and exist in the plasma and on cell surfaces as inactive precursors (zymogens).
Complement System - Immunology; Allergic Disorders - Merck …
The complement system is an enzyme cascade that helps defend against infection via activation of a local inflammatory response. Many complement proteins occur in serum as inactive enzyme precursors (zymogens); others reside on cell surfaces. …
Complement | Description, Function, & Activation | Britannica
2024年12月4日 · Complement, in immunology, a complex system comprising a large number of proteins that act in concert to help eliminate infectious microorganisms. Specifically, the complement system causes the lysis (bursting) of foreign and infected cells, the phagocytosis (ingestion) of foreign particles and
The complement system - Autoimmunity - NCBI Bookshelf
2013年7月18日 · The complement system (CS) is one of the first lines of innate immune defense and plays an important role in the homeostasis of adaptive immunity response. In humans, it was identified as the heat-labile component of serum that assists, or complements, the action of antibodies which are in charge of killing bacteria.
Overview of Complement Activation and Regulation - PMC
Complement is an important component of the innate immune system that is crucial for defense from microbial infections and for clearance of immune complexes and injured cells. In normal conditions complement is tightly controlled by a number of fluid-phase and cell surface proteins to avoid injury to autologous tissues.
Complement: a key system for immune surveillance and …
2010年8月19日 · By eliminating cellular debris and infectious microbes, orchestrating immune responses and sending 'danger' signals, complement contributes substantially to homeostasis, but it can also take...
A guide to complement biology, pathology and therapeutic
2023年9月5日 · Complement has long been considered a key innate immune effector system that mediates host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader involvement of...