CXCR4 can induce PI3Kδ inhibitor resistance in ABC DLBCL
2018年2月22日 · In the current study, we identified CXCR4 as a cause of primary resistance to idelalisib in ABC DLBCL via gene expression analysis, consistent with earlier studies showing that CXCR4 is...
The pathological role of C-X-C chemokine receptor type 4 (CXCR4…
2023年8月1日 · The CXCR4 overexpression by dependent PI3K/Akt/mTOR signaling pathway was clearly a factor in the development of cancers. Blocking CXCR4-PI3K/Akt/mTOR signaling further could improve chemotherapy sensitivity in tumor cells by reducing the formation of cancer stem cells (CSCs) and EMT and decreasing CXCR4 knockdown [110] .
Frontiers | The Chemokine Receptor CXCR4 in Cell Proliferation …
2020年8月27日 · Ligand binding to CXCR4 activates G protein subunits and the downstream Ca 2+ mobilization from intracellular stores and PI3K/Akt, PLC, and ERK1/2 pathways. This results in gene transcription, cell migration, proliferation and survival.
Circulating tumor cells with metastasis-initiating competence …
2024年5月28日 · Inhibition of CXCR4 signaling through genetic and pharmacologic treatment restored the elevated expressions of PI3K and AKT to the control level but had minimal effect on ERK under shear treatment (Figs. S6c–f). These results suggest that CXCR4 may sense shear force through PI3K-AKT pathway in suspended tumor cells.
CXCR4 Signaling Induced Epithelial-Mesenchymal Transition by PI3K…
Our results showed that SDF-1 can induce AKT and ERK phosphorylation in a dose-dependent manner, and endogenous CXCR4 can be blocked thoroughly by CXCR4 siRNA in U87. Notably SDF-1 alone treatment can induce the upregulation of vementin, snail, and N-cadherin of U87; besides, the downregulation of E-cadherin also occurred.
CXCL12/CXCR4: a symbiotic bridge linking cancer cells and
2015年5月11日 · Recent studies have demonstrated that CXCL12/CXCR4 signaling promotes EMT by activating the MEK/ERK, PI3K/AKT or Wnt/β-catenin pathway in chondrosarcoma, 119 glioblastoma, 120 colorectal cancer...
阻断CXCR4通过PI3K/AKT/mTOR通路促进巨噬细胞自噬缓解冠心 …
本研究旨在探讨趋化因子CXC趋化因子受体4（CXCR4）通过磷酸肌醇3激酶/蛋白激酶B/哺乳动物雷帕霉素靶点（PI3K/AKT/mTOR）通路促进巨噬细胞自噬以缓解冠状动脉疾病的作用。 采集人左冠状动脉和心肌，检测CXCR4、MAP1LC3（LC3）和SQSTM1（p62）的表达。 采用ApoE−/−小鼠建立动脉粥样硬化小鼠模型，采用人单核细胞（THP-1）建立泡沫细胞模型，并使用siRNACXCR4与泡沫细胞共培养。 进行蛋白质印迹来量化 CXCR4、PI3K/AKT/mTOR 通路蛋 …
Targeting a lineage-specific PI3Kɣ–Akt signaling module in acute ...
2024年5月30日 · To address this concern, we developed a proteolysis-targeting chimera (PROTAC) heterobifunctional molecule that specifically degrades PIK3CG and potently suppresses AML progression alone and in...
CXC chemokine receptor 4 (CXCR4) blockade in cancer treatment
2023年3月1日 · CXCL12/CXCR4 axis activates PI3K/AKT pathway, which can upregulate VEGF transcription and protein expression (Liang et al. 2007a), and in contrast, Zagzag et al. revealed that under hypoxic conditions, HIF-1α and VEGF increase the expression of CXCR4 in glioblastoma multiforme (GBM), which boost tumor angiogenesis (Zagzag et al. 2006; Sorkhabi ...
CXCR4 protects bone marrow-derived endothelial progenitor cells …
2021年8月23日 · The present study found that CXCR4 upregulates PI3K and Akt expression in BM-EPCs under hypoxic conditions. In addition, PI3K inhibitor (LY294002) inhibits proliferation and migration, while promoting the apoptosis of CXCR4-mediated BM-EPCs under hypoxic conditions. CXCR4 has been found to be expressed in >23 different types of cancer .