24.8: Reactions of Arylamines - Chemistry LibreTexts
identify the product formed when a given arylamine is reacted with aqueous bromine. give an appropriate example to illustrate the high reactivity of arylamines in electrophilic aromatic substitution reactions. explain why arylamines cannot be used in Friedel‑Crafts reactions.
24.4 Basicity of Arylamines - Chemistry LibreTexts
2023年11月20日 · use the concept of resonance to explain why arylamines are less basic than their aliphatic counterparts. arrange a given series of arylamines in order of increasing or decreasing basicity. discuss, in terms of inductive and resonance effects, why a given arylamine is more or less basic than aniline. Study Notes.
Occurrence, uses, and carcinogenicity of arylamines
2015年1月1日 · Some arylamines are mutagenic, carcinogenic or the cause of other kinds of maladies. Some arylamine are considered the major etiological agents of bladder tumors in humans and animals but may also induce other types of cancers in various organs.
Arylamine | chemical compound | Britannica
In bladder cancer: Risk Factors, Causes, and symptoms. …class of organic chemicals called arylamines. People who work in the leather, rubber, printing, and textiles industries or with large quantities of paint are often exposed to these chemicals and …
24.4: Basicity of Arylamines - Chemistry LibreTexts
2024年9月30日 · This section examines the basicity of arylamines, which is influenced by the resonance of the aromatic ring. In arylamines, the lone pair of electrons on the nitrogen can delocalize into the ring, ….
24.8 Reactions of Arylamines - Organic Chemistry | OpenStax
Diazonium coupling reactions are typical electrophilic aromatic substitutions in which the positively charged diazonium ion is the electrophile that reacts with the electron-rich ring of a phenol or arylamine.
Arylamine N-acetyltransferases: a structural perspective - PMC
Arylamine N-acetyltransferases (NATs; EC 2.3.1.5) catalyse the acetylation reaction (generally classified as a Phase II process) by which an acetyl group from the cofactor acetyl coenzyme A (acetyl CoA) is transferred to the substrates, including drugs and carcinogens.
Primary Arylamine - an overview | ScienceDirect Topics
Certain foods and cooking methods can lead to the formation of a class of arylamine compounds known as heterocyclic amines. As implied, they are structurally different, but contain a primary arylamine substructure either an imidazole or benzene ring.
Arylamine N-acetyltransferases: from drug metabolism and ...
Arylamine N-acetyltransferases (NATs) are polymorphic drug-metabolizing enzymes, acetylating arylamine carcinogens and drugs including hydralazine and sulphonamides. The slow NAT phenotype increases susceptibility to hydralazine and …
Arylamine N-acetyltransferases: from structure to function
Arylamine N-acetyltransferases (NATs) are cytosolic conjugating enzymes which transfer an acetyl group from acetylCoenzyme A to a xenobiotic acceptor substrate. The enzyme has an active site cysteine as part of a catalytic triad with histidine and aspartate.