在新选项卡中打开链接
  1. 青蒿素
    青蒿素化合物
    副作用警告相互作用剂量适应症历史作用机制临床试验
     
  2. Wikipedia
    https://en.wikipedia.org/wiki/Artemisinin

    Artemisinin - Wikipedia

    • Artemisinin and its semisynthetic derivatives are a group of drugs used in the treatment of malaria due to Plasmodium falciparum. It was discovered in 1972 by Tu Youyou, who shared the 2015 Nobel Prize in Physiology or Medicine for her discovery. Artemisinin-based combination therapies (ACTs) are now standard treatment worldwide for P. falciparum malaria as well … 展开

    Medical use

    The World Health Organization (WHO) recommends artemisinin or one of its derivatives ― typically in … 展开

    Adverse effects

    Artemisinins are generally well tolerated at the doses used to treat malaria. The side effects from the artemisinin class of medications are similar to the symptoms of malaria: nausea, vomiting, loss of appetite, and … 展开

    给药途径口服、栓剂
    ATC码P01BE01 (WHO)
    CAS号63968-64-9
    PubChem CID68827
    Chemistry

    An unusual component of the artemisinin molecules is an endoperoxide 1,2,4-trioxane ring. This is the main antimalarial centre of the molecule. Modifications at carbon 10 (C10) position give rise to a variety of derivati… 展开

    Mechanism of action

    As of 2018, the exact mechanism of action of artemisinins has not been fully elucidated. Artemisinin itself is a prodrug of the biologically active dihydroartemisinin. This metabolite undergoes cleavage of its endoperoxide ring … 展开

    Resistance

    Clinical evidence for artemisinin drug resistance in southeast Asia was first reported in 2008, and was subsequently confirmed by a detailed study from western Cambodia. Resistance in neighbouring Thailand was … 展开

    Synthesis

    The biosynthesis of artemisinin is believed to involve the mevalonate pathway (MVA) and the cyclization of farnesyl diphosphate (FDP). It is not clear whether the non-mevalonate pathway can also contribute 5-carbon precursor… 展开

    Production and price

    China and Vietnam provide 70% and East Africa 20% of the raw plant material. Seedlings are grown in nurseries and then transplanted into fields. It takes about 8 months for them to reach full size. The plants are harve… 展开

    CC-BY-SA 许可证中的维基百科文本
    反馈
    内容
    Medical use
    Adverse effects
    简要情况
    Chemistry
    Mechanism of action
    Resistance
    Synthesis
    Production and price
     
  1. 维基百科
    https://zh.wikipedia.org/wiki/青蒿素

    青蒿素 - 维基百科，自由的百科全书

  3. 百度百科
    https://baike.baidu.com/item/青蒿素

    青蒿素 - 百度百科

  4. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S2095809918305423

    Artemisinin, the Magic Drug Discovered from Traditional Chinese ...

  5. Britannica
    https://www.britannica.com/science/arte…

    Artemisinin | Malaria Treatment, Antimalarial Drug

    2024年11月17日 · artemisinin, antimalarial drug derived from the sweet wormwood plant, Artemisia annua. Artemisinin is a sesquiterpene lactone (a compound made up of three isoprene units bound to cyclic organic esters) …

  6. PubChem
    https://pubchem.ncbi.nlm.nih.gov/compoun…

    Artemisinin | C15H22O5 | CID 68827 - PubChem

    (+)-artemisinin is a sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria. It has a role as an antimalarial and a …

  7. 其他用户还问了以下问题
    What is artemisinin derived from?
    Artemisinin (and its various derivatives, which we will refer to collectively as “artemisinin” unless otherwise specified) is a sesquiterpene lactone compound (Fig. 1) with a unique chemical structure derived from the sweet wormwood plant, Artemisia annua L. (Fig. 2).

    Artemisinin, the Magic Drug Discovered from Traditional Chinese

    sciencedirect.com
    What is artemisinin used for?
    Artemisinin and its derivatives have been used for the treatment of malarial and parasitic worm (helminth) infections.

    Artemisinin - Wikipedia

    en.wikipedia.org
    When was artemisinin discovered?
    The crusade launched by the Chinese government in the late 1960s to search for cures for malaria ultimately culminated in the discovery of artemisinin.

    Artemisinin, the Magic Drug Discovered from Traditional Chinese

    sciencedirect.com
    Is artemisinin a cancer drug?
    The anti-malarial artesunate is also active ahainst cancer. Int J Oncol 2001; 18: 767–73. Crespo-Ortiz MP, Wei MQ . Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug. J Biomed Biotech 2012; 2012: 247597.

    Qinghaosu (artemisinin): Chemistry and pharmacology | Acta

    nature.com
    Is Artemisinin an antitumor drug?
    Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug. J Biomed Biotech 2012; 2012: 247597. Li Y, Shan F, Wu JM, Wu GS, Ding J, Xiao D, et al. Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle. Bioorg Med Chem Lett 2001; 11: 5–8.

    Qinghaosu (artemisinin): Chemistry and pharmacology | Acta

    nature.com
    Is artemisinin a true gift from Old Chinese medicine?
    Artemisinin, with its unique sesquiterpene lactone created by phytochemical evolution, is a true gift from old Chinese medicine. The route to the discovery of artemisinin was short compared with those of many other phytochemical discoveries in drug development.

    The discovery of artemisinin (qinghaosu) and gifts from Chinese

    nature.com
    反馈
  8. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC4966551

    The discovery of artemisinin and Nobel Prize in Physiology or …

  9. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S075333222300656X

    Medicinal and mechanistic overview of artemisinin in the …

  10. Nature
    https://www.nature.com/articles/aps2012104

    Qinghaosu (artemisinin): Chemistry and pharmacology …

    2012年8月27日 · Artemisinin (qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action. Mol Biochem Parasitol 1991; 49 : 181–9. Article CAS Google Scholar

  11. Nature
    https://www.nature.com/articles/nm.2471

    The discovery of artemisinin (qinghaosu) and gifts from …

    2011年10月11日 · Artemisinin, with its unique sesquiterpene lactone created by phytochemical evolution, is a true gift from old Chinese medicine.