Amphiphilic drug interactions with model cellular membranes are ...
In this study, the interactions of raclopride, a model amphiphilic drug, were investigated with mixtures of biologically relevant lipids across a range of compositions, revealing the influence of the chain-melting temperature of the lipids upon the rate of acyl hydrolysis.
Combination of Small Molecule Prodrug and Nanodrug Delivery ...
2014年7月31日 · Here, we develop a drug self-delivery system for cancer therapy, in which anticancer drugs can be delivered by themselves without any carriers. To demonstrate this unique approach, an amphiphilic drug–drug conjugate (ADDC) has been synthesized from the hydrophilic anticancer drug irinotecan (Ir) and the hydrophobic anticancer drug ...
Amphiphilic small molecular mates match hydrophobic drugs …
2022年1月1日 · Here, we established a novel drug-mate strategy by studying the formulation of nanodrugs at the molecular level. In the drug-mate combination, the drug is a hydrophobic drug that is poorly soluble in water, and the mate is an amphiphilic small molecule (SMA) that has both hydrophilic and lipophilic properties.
Amphiphilic drug–additive systems in aqueous and organic …
2020年11月15日 · Plentiful pharmacologically active molecules are amphiphilic in nature. Knowledge about self-assembly, aggregate morphology as well as size and interfacial/micellar properties of such drugs in presence of pharmaceutical excipients (surfactants, electrolytes, polymers, hydrotropes, etc.) is vital from the fundamental and practical point of view.
These unique features enable amphiphilic drugs to overcome multiple biological barriers without external carriers. Here we summarize the recent advances in the design of self-delivery amphiphilic drugs, with an emphasis on the molecular design which governs interactions between amphiphilic drugs and their biological surroundings.
Recent Advances in the Design of Self‐Delivery Amphiphilic Drugs …
2019年12月11日 · This is achieved by molecular designs that control the delivery pathways of amphiphilic drugs at organ/tissue, cellular, and intracellular levels. In this review the recent advances in self-delivery amphiphilic drugs and vaccines are highlighted, with emphasis on the underlying design principles and emerging applications.
Amphiphilic drug–additive systems in aqueous and organic …
2020年11月15日 · The analysis of reported data of several amphiphilic systems containing at least one drug or drug–additive in aqueous medium reveal the propensity of such systems to undergo spontaneous aggregation and to have interaction with pharmaceutical excipients through van der Waals, electrostatic, hydrogen bonding and hydrophobic/hydrophilic ...
Aggregation and interfacial phenomenon of amphiphilic drug …
2019年2月6日 · A pharmacologically active drug amitriptyline hydrochloride (AMH) is employed as an antidepressant and it holds a unbendable tricyclic ring as well as a tiny alkylamine chain having a terminal nitrogen particle, furthermore, by reason of the occurrence of hydrocarbon side chain this class of drug forms micelles independently, akin to usual ...
Amphiphilic Molecules, Interfaces and Colloids - MDPI
1 天前 · Amphiphilic molecules contain structural groups with affinity for either “water” or “oil”, two immiscible solvents. Their amphiphilic character determines preferential adsorption at the interface and enables self-assembly into various structures, such as micelles, vesicles, monolayer, bilayers and lamellar phases in the bulk [].These self-assembled structures play essential roles in ...
2023年12月14日 · Moreover, cation amphiphilic drugs (CADs) are known as ASM inhibitors and have anti-cancer activity, but the structural mechanisms of their interactions with the lysosomal membrane and ASM are poorly explored. Our study, leveraging all-atom explicit solvent molecular dynamics simulations, delves into