Growth Hormone Receptor Regulation in Cancer and Chronic …
In this review, we discuss the role of first line effectors that act directly on the GHR at the cell surface including ADAM17, JAK2, SRC family member Lyn, Ubc13/CHIP, proteasome, βTrCP, CK2, STAT5b, and SOCS2. Activity of all, except JAK2, …
Model for growth hormone receptor activation based on …
2005年8月21日 · Growth hormone is believed to activate the growth hormone receptor (GHR) by dimerizing two identical receptor subunits, leading to activation of JAK2 kinase associated with the cytoplasmic domain.
The Growth Hormone Receptor: Mechanism of Receptor Activation…
Growth hormone activates the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling pathway, and recent studies have provided a new understanding of the mechanism of JAK2 activation by growth hormone binding to its receptor.
In Vivo Analysis of Growth Hormone Receptor Signaling Domains and …
Here we report the creation and characterization of the first knockin mouse models designed to determine how and which specific regions of the GHR cytoplasmic domain are required for GH actions observed in vivo.
The growth hormone receptor interacts with transcriptional …
2023年4月12日 · Growth hormone (GH) actions are mediated through binding to its cell-surface receptor, the GH receptor (GHR), with consequent activation of downstream signalling. However, nuclear GHR localisation has also been observed and is …
Structural basis for activation of the growth hormone ... - Nature
2020年10月15日 · Growth hormone-releasing hormone (GHRH) regulates the secretion of growth hormone that virtually controls metabolism and growth of every tissue through its binding to the cognate receptor...
A long-acting GH receptor antagonist through fusion to GH …
2016年10月12日 · We have developed an alternative technology for generating a long acting potent GHR antagonist through translational fusion of a mutated GH linked to GH binding protein and tested three candidate...
Growth Hormone Receptor Regulation in Cancer and Chronic …
2020年11月18日 · Dysregulation of GHR signaling is associated with various diseases and chronic conditions such as acromegaly, cancer, aging, metabolic disease, fibroses, inflammation and autoimmunity. Numerous studies entailing the GHR signaling pathway have been conducted for various cancers.
Growth hormone receptor disrupts glucose homeostasis via promoting …
2021年7月13日 · Recombinant adeno-associated viruses encoding GHR and STAT5 and GHR knockout mice were used to investigate the roles of hepatic GHR in glucose homeostasis. Tissue H&E, Oil Red O and PAS staining were performed for histomorphological analysis.
Regulation of human growth hormone receptor expression by microRNAs
Human GH binds to its receptor (GHR) on target cells and activates multiple intracellular pathways, leading to changes in gene expression, differentiation, and metabolism.