What are PARP inhibitors? - MD Anderson Cancer Center
2024年4月3日 · PARP inhibitors are a type of targeted therapy commonly used to treat breast cancer and ovarian cancer, among others. They target PARP, or poly (ADP-ribose) polymerase, which is a protein in cells that helps repair damaged DNA.
PARP inhibitor - Wikipedia
PARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP). They are developed for multiple indications, including the treatment of heritable cancers. [1] Several forms of cancer are more dependent on PARP than regular cells, making PARP (PARP1, PARP2 etc.) an attractive target for cancer therapy.
What is a PARP inhibitor? Uses, how they work, and options
2021年3月15日 · A PARP inhibitor is a type of prescription drug that helps treat certain types of cancer. It blocks the PARP enzymes in cells. PARP enzymes help repair DNA damage.
List of PARP inhibitors (Poly (ADP-ribose) polymerase inhibitors ...
2023年4月14日 · Poly (ADP-ribose) polymerase inhibitors, also called PARP inhibitors, are targeted therapies that are used to treat cancer. PARP is a protein that has a role in cellular growth, regulation, and cell repair and it helps cancer cells repair themselves and survive.
PARP Inhibitors - Susan G. Komen®
2024年4月12日 · The PARP inhibitors olaparib (Lynparza) and talazoparib (Talzenna) are FDA-approved for the treatment of HER2-negative metastatic breast cancer in people who have a BRCA1 or BRCA2 inherited gene mutation.
Definition of PARP inhibitor - NCI Dictionary of Cancer Terms
A substance that blocks an enzyme in cells called PARP. PARP helps repair DNA when it becomes damaged. DNA damage may be caused by many things, including exposure to UV light, radiation, certain anticancer drugs, or other substances in the environment.
PARP Inhibitors: Clinical Relevance, Mechanisms of Action and …
2020年9月9日 · PARP inhibitors (PARPi) were the first approved cancer drugs that specifically targeted the DNA damage response in BRCA1/2 mutated breast and ovarian cancers.
PARP Inhibitor: Targeted Therapy Drugs for Cancer
2022年1月12日 · PARP inhibitors are drugs that block the DNA-repairing mechanism of PARP. By preventing PARP from repairing the damaged DNA within cancer cells, PARP inhibitors can help kill them.
PARP Inhibitors | Targeted cancer drugs | Cancer Research UK
2024年9月24日 · PARP inhibitors are a type of targeted cancer drug. They are a treatment for several types of cancer including ovarian, breast and prostate cancer. They are also in trials as a treatment for other types of cancer.
How Do PARP Inhibitors Work In Cancer? - Dana-Farber Cancer Institute
2016年7月21日 · PARPs (or Poly (ADP-ribose) polymerases) are proteins that play an important role in the life of a cell. When a strand of the DNA double helix is broken or damaged, PARPs act as a repair crew to help fix the damaged site, allowing the cell to live.