Nanodelivery of nucleic acids | Nature Reviews Methods Primers
2022年4月14日 · Lipid-based nano-delivery systems are the most widely used non-viral nucleic acid vehicle, mainly due to their stable nanostructure in physiological fluids...
Viral and nonviral delivery systems for gene delivery - PMC
One of the successful gene therapy systems available today are viral vectors, such as retrovirus, adenovirus (types 2 and 5), adeno-associated virus, herpes virus, pox virus, human foamy …
Viral vector platforms within the gene therapy landscape
2021年2月8日 · Contemporary viral vector-based gene therapy is achieved by in vivo delivery of the therapeutic gene into the patient by vectors based on retroviruses, adenoviruses (Ads) or …
Nucleic acid delivery for therapeutic applications - ScienceDirect
2021年11月1日 · Nucleic Acids are often encapsulated in delivery vehicles including viral vectors, lipid nanoparticles (LNP), and polymeric complexes. Delivered nucleic acid drugs must evade …
Technological advances in the use of viral and non-viral vectors …
2023年6月10日 · Contrary to the dependence on the EPR effects by non-viral drug delivery systems for their mechanisms of action, the design of viral vector purportedly aims at shielding …
Drug delivery systems for RNA therapeutics - Nature
2022年1月4日 · RNA can be ferried into cells using non-viral drug delivery systems, which circumvent the limitations of viral delivery vectors. Here, we review the growing number of …
Safe and effective in vivo delivery of DNA and RNA using …
2024年9月10日 · Given the strengths and limitations of current viral and non-viral approaches, we developed a proteolipid vehicle (PLV) platform that incorporates an engineered viral fusion …
Next‐Generation Vaccines: Nanoparticle‐Mediated DNA and mRNA Delivery …
As injecting naked DNA/mRNA into the body will lead to quick degradation via endonucleases, there is a need for special methods to enhance the nucleic acid vaccine delivery. Vectors are …
Virus-inspired nucleic acid delivery system: Linking virus and viral ...
2016年11月15日 · More recently, rationally designed self-assembly protein/peptide-based structural viral mimicry (PSVM) has emerged as a new class of nucleic acid delivery vehicles. …
Research Progress of nucleic acid delivery vectors for gene therapy
2020年1月27日 · This review presents the current types of nucleic acid delivery vehicles, which focuses on comparing their respective advantages and limitations, and proposes a novel …