Understanding CD30 biology and therapeutic targeting: a ... - Nature
2017年9月8日 · CD30 ligand (CD30L, also known as TNFSF8 or CD153) is a membrane-bound cytokine with sequence homology to other members of the tumor necrosis factor (TNF) family. 4 CD30L can be detected in...
TNFRSF8 protein expression summary - The Human Protein Atlas
This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Tissue expression of TNFRSF8 - Summary - The Human Protein …
Summary of TNFRSF8 (CD30, D1S166E, KI-1) expression in human tissue. Cytoplasmic and membranous expression mainly in subsets of immune cells.
Targeting the TNF and TNFR superfamilies in autoimmune disease …
2024年10月24日 · The bispecific T cell engager is designed to stabilize T cell–tumour cell proximity by targeting both BCMA that can be expressed on B cell tumours and CD3 to activate T cells.
TNFRSF8 Gene - GeneCards | TNR8 Protein | TNR8 Antibody
2024年10月2日 · This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
The Polyvalent Role of CD30 for Cancer Diagnosis and Treatment
CD30L, commonly known as CD153, is a type II transmembrane protein belonging to the TNF superfamily 8 (TNFSF8). The human CD30L gene can be found on chromosome 9q33, and CD30L is expressed in both resting and activated B cells, activated T cells, natural killer (NK) cells, eosinophils granulocytes, monocytes, and mast cells.
Signaling by the TNFR superfamily in B-cell biology and disease
B-cell compartmentalization and cell-cell interactions in the secondary lymphoid tissues require expression of membrane-bound LTα/β trimers and TNF, whereas T-cell-dependent B-cell differentiation requires engagement of CD40 (TNFRSF5) by CD40L on activated CD4 + T cells. CD30 (TNFRSF8) is expressed on activated B cells and has been found to ...
TNFRSF8 Expression - My Cancer Genome
TNFRSF8 Expression is a predictive biomarker for use of brentuximab vedotin in patients. Of the therapies with TNFRSF8 Expression as a predictive biomarker, 1 is FDA-approved in at least one clinical setting.
Targeting CD30/CD30L in Oncology and Autoimmune and
Part of the book series: Advances in Experimental Medicine and Biology ( (AEMB,volume 647)) The transmembrane receptor CD30 (TNFRSF8) and its ligand CD30L (CD153, TNFSF8) are members of the tumor necrosis factor (TNF) superfamily and display restricted expression in subpopulations of activated T-and B-cells in nonpathologic conditions.
The Polyvalent Role of CD30 for Cancer Diagnosis and Treatment
2023年7月5日 · CD30L, commonly known as CD153, is a type II transmembrane protein belonging to the TNF superfamily 8 (TNFSF8). The human CD30L gene can be found on chromosome 9q33, and CD30L is expressed in both resting and activated B cells, activated T cells, natural killer (NK) cells, eosinophils granulocytes, monocytes, and mast cells.