Pathology Outlines - SCC-general
Feb 2, 2024 · Ultraviolet (UV) radiation for lip squamous cell carcinoma (Laryngoscope 2018;128:84) High risk human papillomavirus (HPV) is strongly associated with oropharyngeal squamous cell carcinoma; in contrast, 4.4% of oral squamous cell carcinoma cases are associated with high risk HPV (Braz J Otorhinolaryngol 2021;87:346)
Pathology Outlines - Cutaneous fibroepithelial polyps
Jan 24, 2022 · Verruca vulgaris / squamous cell papilloma (Australas J Dermatol 2019;60:70): Epidermal papillomatosis with coarse hypergranulosis May have koilocytosis Hyperkeratosis with columns of parakeratosis Melanocytic nevus (Arch Dermatol 1996;132:1459): Melanocytic proliferation within the polyp Commonly intradermal or compound
Pathology Outlines - HPV associated squamous cell carcinoma-vulva
Feb 6, 2024 · 22 year old woman with HPV positive squamous cell carcinoma of the vulva (Gynecol Oncol Rep 2021:36:100760) 58 year old woman with warty squamous cell carcinoma and condylomata acuminata (Med Arch 2017;71:72) 63 year old woman with combined squamous cell carcinoma and Merkel cell carcinoma (JAAD Case Rep 2015;1:196)
Pathology Outlines - Seborrheic keratosis
May 17, 2022 · Lack of atypia. Seborrheic keratosis is a benign keratinocyte proliferation that lacks atypia and dysplasia. Acanthosis and papillomatosis (A) are features of seborrheic keratosis but can also be seen in squamous cell carcinoma. Atypical mitotic figures (B) are a feature of squamous cell carcinoma.
HPV associated cervical squamous cell carcinoma
Dec 11, 2023 · Most cervical squamous cell carcinomas are associated with human papilloma virus (HPV) 18 Nearly all cases of cervical squamous cell carcinoma are associated with high risk HPV and arise from a precursor lesion, high grade squamous intraepithelial lesion (HSIL)
Pathology Outlines - HPV associated
Nov 20, 2019 · U.S. incidence of oropharyngeal HPV+ squamous cell carcinoma is higher than the incidence of HPV- cases, 4.62 versus 1.82 per 100,000 (Cancer Epidemiol Biomarkers Prev 2019;28:1660) Patients are younger, predominantly Caucasians and higher socioeconomic status compered to HPV- squamous cell carcinoma
Pathology Outlines - Warts (verrucae)
Jun 7, 2021 · The virions are sloughed off with the dead squamous cells of the host epithelium for further transmission (Front Biosci (Landmark Ed) 2018;23:1587) Etiology More than 200 types of HPV ( J Dtsch Dermatol Ges 2019;17:613 )
Pathology Outlines - Conjunctival intraepithelial neoplasia
Jun 21, 2024 · HPV 6 and 11 (choice A) are associated with squamous papilloma. HPV 16 and 18 are associated with conjunctival intraepithelial neoplasia. Goblet cell containing epithelium without dysplasia (choice B) is seen in other entities that may mimic conjunctival intraepithelial neoplasia, such as pterygium, pingueculae and squamous papilloma.
Pathology Outlines - Verrucous carcinoma
Jun 8, 2023 · These findings are consistent with verrucous carcinoma. Answers A, B and C are incorrect because condyloma acuminatum, squamous papilloma and verruca vulgaris all may demonstrate exophytic papillary projections; however, all 3 of these entities should demonstrate some degree of circumscription (perhaps inward cupping rate ridges) and symmetry.
Pathology Outlines - Sinonasal carcinoma-general
Jun 29, 2023 · Histologic grade does not have prognostic value in sinonasal squamous cell carcinoma but molecular markers do EGFR overexpression and HPV negativity in squamous cell carcinoma is associated with worse prognosis p16 overexpression with EGFR negativity has a better prognosis References: Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420