SARS-CoV-2 infects coronary arteries, increases plaque inflammation
2023年9月28日 · To test their theory, Giannarelli and her team took tissue from the coronary arteries and plaque of people who had died from COVID-19 and confirmed the virus was in those tissues. Then they took arterial and plaque cells – including macrophages and foam cells – from healthy patients and infected them with SARS-CoV-2 in a lab dish.
Plaque-eating nanoparticles may help prevent heart attacks
2020年1月27日 · Researchers are reporting development of a new type of nanoparticle that eats away portions of plaque, the fatty deposits in the arteries that trigger heart attacks and strokes. The plaque-munching particles showed promise in laboratory studies in mice as a potential treatment for atherosclerosis, a leading cause of death. The team of ...
Atherosclerosis - What Is Atherosclerosis? | NHLBI, NIH
2024年10月28日 · Carotid artery disease is plaque buildup in the neck arteries. It reduces blood flow to the brain. Coronary artery disease (CAD) is plaque buildup in the arteries of your heart. Peripheral artery disease (PAD) most often is plaque buildup in the arteries of the legs, but it can also build up in your arms or pelvis.
How Smoking Affects the Heart and Blood Vessels - NHLBI, NIH
2022年3月24日 · It can damage the heart and blood vessels of people who don’t smoke in the same ways that smoking causes damage to people who do. The image shows how smoking can affect arteries. Figure A shows the location of coronary heart disease and peripheral artery disease. Figure B shows a leg artery with plaque buildup partially blocking blood flow.
What Is Coronary Heart Disease? - NHLBI, NIH
2023年12月20日 · The cause of coronary heart disease depends on the type. Coronary artery disease is often caused by cholesterol, a waxy substance that builds up inside the lining of the coronary arteries, forming plaque. This plaque buildup can partially or totally block blood flow in the large arteries of the heart.
Coronary Heart Disease - Causes and Risk Factors - NHLBI, NIH
2023年12月20日 · When plaque builds up inside the arteries that supply blood to the heart muscle, those coronary arteries harden and become narrower over time. This can lower or block blood flow to the heart muscle, preventing the heart from getting enough oxygen-rich blood. This is the main cause of obstructive coronary artery disease. Normal versus a blocked ...
Heart Attack - Causes and Risk Factors - NHLBI, NIH
2022年3月24日 · The buildup of this plaque is called atherosclerosis. This can happen over many years, and it can block blood flow to parts of your heart muscle. Plaques that narrow arteries slowly over time cause angina. Eventually, an area of plaque can break open inside your artery. This causes a blood clots to form on the plaque’s surface. If the clot ...
Atherosclerosis - Causes and Risk Factors | NHLBI, NIH
2024年10月28日 · As the plaque grows, the artery narrows, reducing the flow of oxygen-rich blood to the limbs and organs. Over time, plaque can break up and flow into the bloodstream. This may lead to blood clots , which can block blood flow. If this happens, nearby tissue can't get enough oxygen and may die, causing a heart attack, stroke, or limb pain.
Atherosclerosis - Treatment - NHLBI, NIH
2024年10月28日 · Angioplasty opens narrowed or blocked arteries. Healthcare providers may use angioplasty to treat peripheral artery disease affecting the legs, to treat coronary heart disease in the arteries of the heart, or to treat carotid artery disease in the neck. Your provider may inflate a small balloon in the artery to help flatten the plaque.
What Is Peripheral Artery Disease? - NHLBI, NIH
2022年3月24日 · In the United States, more than 8 million people ages 40 and older have peripheral artery disease, or PAD. Also called peripheral arterial disease, PAD is caused by atherosclerosis, or plaque buildup, that reduces the flow of blood in peripheral arteries — the blood vessels that carry blood away from the heart to other parts of the