PARP - 百度百科
parp是存在于多数 真核细胞 中的一个多 功能蛋白 质 翻译后 修饰酶。 它通过识别结构损伤的 dna 片段而被激活，被认为是 dna损伤 的 感受器 。 它还能对许多 核蛋白 进行聚 腺苷二磷酸 核糖 …
PARP1 Gene - GeneCards | PARP1 Protein | PARP1 Antibody
2024年10月2日 · PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such …
The multifaceted roles of PARP1 in DNA repair and chromatin
2017年7月5日 · Recent insights into the roles of poly(ADP-ribose) polymerase 1 (PARP1) in mediating various DNA repair pathways, stabilizing DNA replication and modulating chromatin …
PARP1-dependent DNA-protein crosslink repair - Nature
2024年8月5日 · Nature Communications - The authors identify a DNA-protein crosslink (DPC) repair pathway orchestrated by poly-ADP-ribosylation. In this process, PARP1 PARylates the …
PARP1 roles in DNA repair and DNA replication: The basi(c)s of …
2024年2月1日 · PARP1 is a major sensor of DNA breaks with established and putative roles in a number of pathways within the DNA repair network, including repair of single- and double …
EZH2 directly methylates PARP1 and regulates its activity in …
5 天之前 · In recent years, PARP1 has emerged as a promising therapeutic target in cancer treatment. By blocking its enzymatic activity and trapping PARP1 on DNA, PARP1 inhibitor …
PARP1 is a versatile factor in the regulation of mRNA ... - Nature
2019年3月6日 · PARP1 binds RNA and its depletion results in increased expression of genes involved in nonsense-mediated decay, suggesting that PARP1 might be involved in mRNA …
PARP1: Liaison of Chromatin Remodeling and Transcription
PARP1 regulates transcription by facilitating local chromatin decondensation at active gene sites. Activated PARP1 mediates H1 PARylation and displacement from chromatin to form …
The expanding universe of PARP1-mediated molecular and …
2022年3月9日 · PARP1 modulates the structure and function of chromatin through the following: (1) regulation of chromatin composition, including histone variants and linker histone; (2) …
PARP1: Structural insights and pharmacological targets for …
2021年7月1日 · This signal recruits DNA repair proteins to the site of DNA damage. PARP1 binding to these sites enhances ADP-ribosylation via allosteric communication between the …
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