Lentivirus - an overview | ScienceDirect Topics
Lentivirus (LV) is an enveloped single-stranded RNA virus of the Retrovirdae family that binds host cell receptors and results in ejection of transgene material into the cytoplasm. By viral reverse transcriptase, DNA is generated and moves into the nucleus to generate viral proteins.
Lentiviral Guide - Addgene
Addgene: Lentiviral Guide. Learn about AAV and antibody materials from user-contributed reports. Analyze a DNA sequence to see restriction sites and map. Browse a digital-only collection of vector backbone information.
Clinical use of lentiviral vectors | Leukemia - Nature
2018年3月22日 · Two unique steps of the retroviral life cycle, reverse transcription and integration, are integral to how lentiviral vectors function. Following uncoating, the remaining viral nucleic acid and ...
Lentivirus (lente-, latin for “slow”) is a group of retroviruses characterized for a long incubation period. They are classified into five serogroups according to the vertebrate hosts they infect: bovine, equine, feline, ovine/caprine and primate. Some examples of lentiviruses are Human (HIV), Simian (SIV) and Feline (FIV) Immunodeficiency Viruses.
The Inside Out of Lentiviral Vectors - PMC
Abstract. Lentiviruses induce a wide variety of pathologies in different animal species. A common feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a property that constitutes an extremely attractive asset in gene therapy.
Lentivirus Fact Sheet – Stanford Environmental Health
Lentivirus Fact Sheet. The genus of the family Retroviridae consists of non-oncogenic retroviruses that produce multi-organ diseases characterized by long incubation periods and persistent infection. Five serogroups are recognized, reflecting …
Genus: Lentivirus | ICTV
The viruses in the genus include exogenous viruses of humans and many other mammals that are transmitted horizontally and vertically (Evans et al., 2013, Freed and Martin 2013). Five groups of lentiviruses can be clustered on the basis of the hosts they infect (primates, sheep and goats, horses, cats and cattle) (Gifford 2012, Evans et al., 2013).
The Revival of Lentiviral Vectors - Nature
Lentivirus-based vectors are increasingly used in gene and cell therapy research because theyhave the ability to infect dividing and non-dividing cells, low cytotoxicity rate, capacity for...
Lentivirus Production - PMC
Lentiviruses, such as the Human Immunodeficiency Virus, are capable to infecting both dividing and non-dividing cells. We will describe a procedure which to package lentiviruses. Packaging refers to the preparation of competent virus from DNA vectors.
A Guide to Approaching Regulatory Considerations for …
Lentiviral vectors are increasingly the gene transfer tool of choice for gene or cell therapies, with multiple clinical investigations showing promise for this viral vector in terms of both safety and efficacy.
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