Lactam - Wikipedia
A lactam is a cyclic amide, formally derived from an amino alkanoic acid through cyclization reactions. The term is a portmanteau of the words lactone + amide . Nomenclature
Beta-Lactam Antibiotics - StatPearls - NCBI Bookshelf
2023年6月4日 · Beta-lactam antibiotics are used in the management and treatment of bacterial infections. This activity will highlight the mechanism of action, adverse event profile, and other …
β-Lactams and β-Lactamase Inhibitors: An Overview - PMC
β-Lactam antibiotics are bactericidal agents that interrupt bacterial cell-wall formation as a result of covalent binding to essential penicillin-binding proteins (PBPs), enzymes that are involved in …
β-Lactamases: Sequence, Structure, Function, and Inhibition
Rather than an active-site serine, these enzymes employ a hydroxide that is activated by coordination to the Zn(II) ion(s) as the nucleophile initiating β-lactam hydrolysis.
β-Lactam - Wikipedia
A lactam is a cyclic amide, and beta-lactams are named so because the nitrogen atom is attached to the β-carbon atom relative to the carbonyl. The simplest β-lactam possible is 2-azetidinone. …
β-Lactams: chemical structure, mode of action and mechanisms of ... - LWW
2012年6月20日 · Of the β-lactam antibiotics that are currently available, all feature the reactive β-lactam ring system, a highly strained and reactive cyclic amide. There are five relevant ring …
β-Lactam antibiotic - Wikipedia
β-Lactam antibiotics (beta-lactam antibiotics) are antibiotics that contain a β-lactam ring in their chemical structure. This includes penicillin derivatives , cephalosporins and cephamycins , …
Lactam - an overview | ScienceDirect Topics
A lactam is a cyclic amide, which can be found in different forms: α-lactam (three-atom rings), β-lactam (four-atom rings), γ-lactam (five-atom rings), δ-lactam (six-atom rings), and ɛ-lactam …
β-Lactams and β-Lactamase Inhibitors: An Overview - PubMed
2016年8月1日 · β-Lactams are the most widely used class of antibiotics. Since the discovery of benzylpenicillin in the 1920s, thousands of new penicillin derivatives and related β-lactam …
β-lactam antibiotics: An overview from a medicinal chemistry ...
2020年12月15日 · β-Lactam antibiotics are one of the most relevant drug classes of antibacterial agents worldwide. The discovery and the market of first β-lactam antibiotic (Penicillin G) is a …