Environmental Isocyanate-Induced Asthma: Morphologic and …
2011年9月9日 · The resulting isocyanate asthma accounts for the leading causes of occupational induced asthma bronchial worldwide. After sensitization even very small amounts of isocyanate can induce asthmatic reactions.
Isocyanates - Overview - Occupational Safety and Health Administration
Isocyanates include compounds classified as potential human carcinogens and known to cause cancer in animals. The main effects of hazardous exposures are occupational asthma and other lung problems, as well as irritation of the eyes, nose, throat, and skin.
Diagnosis and prevention of diseases induced by isocyanate
Isocyanates are among the most frequent causes of occupational asthma in industrialized countries. Early diagnosis of diisocyanate asthma followed by prompt termination of chemical exposure can prevent chronic morbidity due to persistent asthma. Chronic exposure to isocyanates also induces hypersensitivity pneumonitis (HP).
Occupational Asthma Caused by Isocyanates | Patterns of …
Inhalation challenges to isocyanates are conducted in specialized centers to confirm occupational asthma. The pattern of asthmatic reactions due to consecutively increasing daily doses of isocyanates is unknown.
Skin Exposure to Isocyanates: Reasons for Concern - PMC
Isocyanates (di- and poly-), important chemicals used worldwide to produce polyurethane products, are a leading cause of occupational asthma. Respiratory exposures have been reduced through improved hygiene controls and the use of less-volatile isocyanates.
Isocyanates and Work-Related Asthma: Findings From California ...
The physiologic mechanism of how isocyanates cause asthma is not fully understood. Nevertheless, the lag between exposure and symptom onset along with the recurrence of asthma attacks from re-exposure to low concentrations are consistent with an immune-mediated model [Woodbury, 1956; Wisnewski and Jones, 2010].
Is Isocyanate Exposure and Occupational Asthma Still a Major
2021年12月14日 · Asthma is the most frequent manifestation of prolonged exposure. We assessed the evolution of the incidence of isocyanate-induced occupational asthma over time. PubMed and Cochrane databases were systematically searched for studies published since 1990 that assessed the relationship between occupational exposure to isocyanates and asthma.
Isocyanates and human health: Multi-stakeholder information …
Diisocyanates and polyisocyanates, commonly referred to as isocyanates, are a family of highly reactive chemicals and one of the most frequently reported causes of occupational asthma. The most common isocyanates include, but are not limited to, toluene diisocyanate (TDI), methylenebis (phenyl isocyanate)(MDI), and hexamethylene diisocyanate ...
Biomarkers Predicting Isocyanate-Induced Asthma - PMC
2011年3月1日 · Three diisocyanates can cause occupational asthma (OA): toluene diisocyanate (TDI), 4,4 diphenylmethane diisocyanate (MDI), and 1,6-hexamethylene diisocyanate (HDI). We analyzed potential biomarkers of isocyanate-induced OA, based on investigated immunologic, genetic, neurogenic, and protein markers, because there is no serological testing method.
Isocyanates - WorkSafeBC
Short-term exposure to isocyanates can cause minor health issues. Long-term exposure can cause a form of asthma. Workers can also become so sensitive to isocyanates that they can no longer work when the chemicals are present.