Hydroxamic acid - Wikipedia
In organic chemistry, hydroxamic acids are a class of organic compounds having a general formula R−C(=O)−N(−OH)−R' bearing the functional group −C(=O)−N(−OH)−, where R and R' are typically organyl groups (e.g., alkyl or aryl) or hydrogen.
Hydroxamic Acid - an overview | ScienceDirect Topics
Hydroxamic acid refers to a potent zinc chelator that is commonly found in compounds such as matrix metalloproteinase inhibitors and HDAC inhibitors. It binds to the active site of HDACs by coordinating with the zinc cation and establishing hydrogen …
Hydroxamic Acid - an overview | ScienceDirect Topics
Hydroxamic acids. Hydroxamic acids are metal chelators, which can scavenge the zinc ions necessary for HDAC activity. Furthermore, they can bind to the active site of HDACs [51]. The hydroxamic acid HDACIs most studied in pancreatic cancer are trichostatin A, vorinostat, panobinostat and belinostat (Table 1) [52].
Hydroxamic acid – A novel molecule for anticancer therapy
Hydroxamic acid is a potent moiety not only in the field of cancer therapy but also as a mutagenic agent. Among the various derivatives of hydroxamic acid, SAHA (Suberoylanilide Hydroxamic Acid) is considered as a potent anticancer agent.
Hydroxamic Acid Derivatives: From Synthetic Strategies to ...
Hydroxamic acid is one of the most interesting moieties in medicinal chemistry, due to its ability to chelate metal ions, such as Fe(III) and Zn(II). This ability is exploited for the development of various compounds able to inhibit different metalloenzymes, such as …
Hydroxamic Acid Derivatives: From Synthetic Strategies to ...
2021年8月20日 · Hydroxamic acid (HA) derivatives represent a group of relevant scaffolds that find widespread application among the chemical sciences.
Hydroxamic Acid - an overview | ScienceDirect Topics
Hydroxamic acids are the most widely explored class of HDACis. Essential characteristics of hydroxamic acid-based molecules are the polar hydroximic group, a four–six carbon hydrophobic methylene spacer (CU, polar connection unit), a second polar