Antimicrobial Resistance Threats - National Institute of Allergy and ...
Gram-Negative Bacteria. The Gram stain test, developed in the 1800s by Hans Christian Gram, is a method for classifying different types of bacteria using a chemical stain and viewing through a microscope the results on the bacteria’s protective cell wall.
Develop Tools to Tackle Antibiotic-Resistant Gram-Negative Bacteria
2024年5月15日 · Gram-negative bacterial pathogens such as carbapenem-resistant Acinetobacter, carbapenem-resistant Enterobacterales (CRE), and multidrug-resistant (MDR) Pseudomonas aeruginosa pose grave risks to public health, especially due to the lack of effective therapeutic options to treat some of these infections—an issue that’s exacerbated by the ...
Can Improved Tests Speed Up Treatment for Antibacterial …
2024年10月25日 · The FAST trial has enrolled hospitalized participants with Gram-negative bacteria identified in their blood. Such bacteria include Klebsiella species and Escherichia coli . They have been randomized to one of two groups: half the participants are having their blood cultures tested with VITEK ® REVEAL™ as well as standard bacterial culture ...
Recent NIAID Research Initiatives on Antimicrobial Resistance
Targeting Resistance in Select Gram-Negative Pathogens; FY 11. Development of Therapeutics for Biodefense; Partnerships for Biodefense; FY 10. Partnerships for Development of Therapeutics and Diagnostics for Drug-Resistant Bacteria and Eukaryotic Parasites (R01)
Shigellosis - National Institute of Allergy and Infectious Diseases …
2024年4月11日 · Shigellosis is a diarrheal disease caused by infection with Shigella bacteria. Transmission of Shigella usually occurs through contact with the “4 Fs,” which are food, feces, flies, and fomites (inert surfaces). It also can also be spread through sexual contact.
Synthetic Tetracyclines To Combat Bacterial Infections
2022年5月13日 · Tetracyclines are broad-spectrum antibiotics used to treat bacterial infections, but many bacteria are developing resistance to treatment. NIAID is supporting the development of novel tetracyclines that are not subject to existing tetracycline resistance mechanisms and therefore represent important new tools for the treatment of multidrug-resistant (MDR) …
Antibacterial Resistance Leadership Group (ARLG)
ARLG is a major clinical effort to address antibacterial resistance (AR) including collaborations in 19 countries and over 40 clinical research studies involving more than 20,000 volunteers. Studies include clinical testing of new drugs to treat multidrug-resistant Gram-negative bacteria, evaluating diagnostic devices in clinical settings, and optimizing treatment regimens to reduce the ...
Rapid Diagnostics to Combat Antimicrobial Resistance
2024年11月15日 · This panel tests for 24 Gram-positive bacteria, Gram-negative bacteria, and yeast microbes that cause bloodstream infections (sepsis). The future assay under development will simultaneously tests for 24 pathogens; Gram-positive bacteria, Gram-negative bacteria, and yeast microbes that cause bloodstream infections (sepsis) within 2 hours of ...
January 2024 DMID Council-Approved Concepts
2024年8月2日 · For the published request for applications, check the April 1, 2024 Guide announcement, Partnerships for the Development of Tools to Advance Therapeutic Discovery Antibiotic-Resistant Gram-Negative Bacteria (R01 Clinical Trial Not Allowed). Promoting Innovative Research in Treponema pallidum Pathogenesis
alarming rate. This includes resistance among gram-negative bacteria, which have acquired and spread new resistance traits especially rapidly over the past decade. In 2013, the Centers for Disease Control and Prevention (CDC) published a list of “urgent,” “serious,” and “concerning” domestic AR threats . 7. The CDC updated this ...